Results 141 to 150 of about 29,714,140 (226)

Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi‐Target Therapy in Psychiatric Disorders

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Longgu (fossilized bone) delivers a natural synergistic network of metal ions, Ca2+, Mg2+, Zn2+, Fe, Cu, and Mn2+ that collectively targets the interconnected pathologies of anxiety, depression, and insomnia. This multi‐ion system operates through coordinated mechanisms including ionostatic balance, cross‐pathway synergy, and systemic integration ...
Sun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen   +7 more
wiley   +1 more source

Propofol improved hypoxia-impaired integrity of blood-brain barrier via modulating the expression and phosphorylation of zonula occludens-1. [PDF]

CNS Neurosci Ther, 2019
Chen W, Ju XZ, Lu Y, Ding XW, Miao CH, Chen JW.   +5 more
europepmc   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Cannabidiol Ameliorates Blood–Brain Barrier Dysfunction and Inhibits Memory Astrocytes Activation in Mice With Sickness‐Like Behaviors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Depressive‐like mice showed blood–brain barrier disruption with loss of endothelial tight junction proteins, astrocytic AQP4 depolarization, and elevated neuroinflammation. A single dose of cannabidiol restored BBB integrity and astrocyte polarity, suppressed memory astrocyte–mediated secondary neuroinflammation, and alleviated depressive‐like ...
Yue Chen, Hui Ma, Qian Long, Xuan Fang, Xiaotong Li, Wenhui Xiao, Xinzhou Deng, Fuze Du, Yifei Tan, Yan Wang, Xiaoxia Jiang, Bo Gao, Xin Qiao   +12 more
wiley   +1 more source

Involvement of Zonula Occludens proteins in metastatic lung cancer progression.

, 2016
Au cours de la conversion métastatique des tumeurs épithéliales, les cellules tumorales acquièrent des capacités invasives/migratoires nouvelles. Ce changement phénotypique est associé au processus de TEM durant lequel les composants des jonctions ...
Lesage, Julien
core  

Study on the Relationship between Zonula Occludens-1 and Digestive System Diseases

Advances in Clinical Medicine, 2022
openaire   +1 more source

Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia, Chang Liang, Zhuoqing Zhuang, Pingrun Chen, Zhe Xiong, Junzhu Lu, Yan Zhang   +6 more
wiley   +1 more source

Toll-Like Receptor 4 Reduces Occludin and Zonula Occludens 1 to Increase Retinal Permeability Both in vitro and in vivo. [PDF]

J Vasc Res, 2017
Liu L, Jiang Y, Steinle JJ.
europepmc   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1187-1200, September 2026.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Neuroprotective effects of ulinastatin on Escherichia coli meningitis rats through inhibiting PKCα phosphorylation and reducing zonula occludens-1 degradation. [PDF]

Sci Rep
Zheng X, Wang J, Su H, Wu L, Zhang Y, Tang Q, Ban T, Xie K, Wei C, Lin C.   +9 more
europepmc   +1 more source