Results 201 to 210 of about 29,714,140 (226)
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Elevated systemic zonula occludens 1 is positively correlated with inflammation in cirrhosis
Clinica Chimica Acta, 2018It has been well established that disruption of the intestinal barrier function and increased intestinal permeability contribute to endotoxemia and associated liver injury in patients with cirrhosis. However, the relationship between systemic inflammation and tight junction protein in cirrhosis remain unidentified.
Ashwini Karthikeyan +3 more
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Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers
Cell and Tissue Research, 2021Tight junctions (TJs) firmly seal epithelial cells and are key players in the epithelial barrier. TJs consist of several proteins, including those of the transmembrane claudin family and the scaffold zonula occludens (ZO) family. Epithelial tissues are exposed to different conditions: to air in the stratified epithelium of the skin and to liquids in ...
Keisuke Imafuku +5 more
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FEMS Microbiology Letters, 2001 In the present study, we report the preliminary characterization of the epithelial cell receptor for Vibrio cholerae zonula occludens toxin (Zot). Zot receptor was purified by ligand-affinity chromatography.
Sérgio Uzzau, Alessio Fasano
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Microvascular Research, 2015
Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial junction complexes that control blood-brain barrier (BBB) integrity. The goal of the current paper was to improve our understanding of how proinflammatory cytokines modulate ZO-1 properties within the human BBB microvascular endothelium.
Philip Cummins, Keith D Rochfort
exaly +3 more sources
Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial junction complexes that control blood-brain barrier (BBB) integrity. The goal of the current paper was to improve our understanding of how proinflammatory cytokines modulate ZO-1 properties within the human BBB microvascular endothelium.
Philip Cummins, Keith D Rochfort
exaly +3 more sources
Zonula Occludens-1 and HER-2/neu Expression in Invasive Breast Carcinoma
Applied Immunohistochemistry & Molecular Morphology, 2003A subset of breast carcinomas shows unexplained overexpression of HER-2/neu protein without HER-2/neu gene amplification. These tumors are often scored 2+ by immunohistochemistry (DAKO HercepTest). In vitro, Zonula occludens-1 (ZO-1), a tight junction protein, can upregulate HER-2/neu expression by sequestering a repressor of the HER-2/neu gene ...
Julie, Bell +3 more
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Zonula occludens‐1/NF‐κB/CXCL8: a new regulatory axis for tumor angiogenesis [PDF]
The FASEB Journal, 2017 Zonula occludens‐1 (ZO‐1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO‐1 in CXCL8/IL‐8 chemokine expression in lung and breast tumor cells.
Lesage, Julien +10 more
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Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats
Cancer Chemotherapy and Pharmacology, 2010The molecular mechanisms that underlie the methotrexate (MTX)-mediated disruption of intestinal barrier function have not been fully characterized. Epithelial barrier function is determined in large part by a multiprotein complex located at the most apical part of the lateral membrane, which is referred to as a tight junction (TJ). In the present study,
Kazuma, Hamada +3 more
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Effect of hepatocyte growth factor on assembly of zonula occludens-1 protein at the plasma membrane
Journal of Cellular Physiology, 1998Hepatocyte growth factor (HGF) is a paracrine cytokine that influences epithelial morphogenesis by modulating cell-cell adhesion and cell polarity. We have examined the role of HGF in the tight junction (TJ) formation. We followed the assembly and disassembly at the plasma membrane of the major component of the TJ, zonula occludens-1 (ZO-1) protein ...
GRISENDI S., ARPIN M., CREPALDI, Tiziana
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Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1)
Mechanisms of Ageing and Development, 2003The endothelial or epithelial tight junctions create a rate-limiting barrier to diffusion of solutes. A major determinant of the barrier function is the density of tight junction proteins. Since aging is associated with significant alterations in the blood-brain barrier (BBB) it is possible that specific tight junction proteins may be altered in the ...
Arshag D, Mooradian +2 more
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The Second PDZ Domain of Zonula Occludens-1 Is Dispensable for Targeting to Connexin43 Gap Junctions
Cell Communication & Adhesion, 2008Zonula occludens (ZO)-1 is emerging as a central player in the control of gap junction (GJ) dynamics. Previously the authors reported that ZO-1 localizes preferentially to the periphery of Cx43 GJs. How ZO-1 arrives at GJ edges is unknown, but this targeting might involve we established interaction between the Cx43 C-terminus and the PDZ2 domain of ZO ...
Andrew W, Hunter, Robert G, Gourdie
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