Biomolecules, 2020 Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin cytoskeleton in the regulation of ...
Randy E. Strauss, Robert G. Gourdie
doaj +1 more source
Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation. [PDF]
, 2020 Background & aimsBiotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis.
Cahalan, Michael D +5 more
core
Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]
, 2006 Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Balda, MS +6 more
core +1 more source
Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin [PDF]
, 2020 Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood.
Baltazar, Murielle +11 more
core +4 more sources
Zonula Occludens‐1 and ‐2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions
Annals of the New York Academy of Sciences, 2009 The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human health, but we still lack a detailed mechanistic knowledge of how the barrier is formed during development or responds to pathological and pharmacological insults. This limits our understanding of barrier dysfunction in disease and slows the development
A. Fanning, James M. Anderson
semanticscholar +4 more sources
Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
core +3 more sources
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases. [PDF]
PLoS ONE, 2012 BACKGROUND: Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available.
Ariadna Mendoza-Naranjo +11 more
doaj +1 more source
Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. [PDF]
, 2006 OBJECTIVE: Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release
Carroccio A +13 more
core +1 more source
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17. [PDF]
PLoS ONE, 2016 Tight junction (TJ) dysfunction in the stratum granulosum leads to aberrant barrier function of the stratum corneum (SC) in the epidermis. However, it is unclear whether TJs are perturbed in atopic dermatitis (AD), a representative aberrant SC-related ...
Takuo Yuki +4 more
doaj +1 more source
Zonula Occludens-1 Alters Connexin43 Gap Junction Size and Organization by Influencing Channel Accretion [PDF]
Molecular Biology of the Cell, 2005 Regulation of gap junction (GJ) organization is critical for proper function of excitable tissues such as heart and brain, yet mechanisms that govern the dynamic patterning of GJs remain poorly defined. Here, we show that zonula occludens (ZO)-1 localizes preferentially to the periphery of connexin43 (Cx43) GJ plaques.
Andrew W, Hunter +3 more
openaire +2 more sources