Results 91 to 100 of about 29,405 (257)

Detailed regulatory mechanism of the interaction between ZO-1 PDZ2 and connexin43 revealed by MD simulations. [PDF]

PLoS ONE, 2011
The gap junction protein connexin43 (Cx43) binds to the second PDZ domain of Zonula occludens-1 (ZO-1) through its C-terminal tail, mediating the regulation of gap junction plaque size and dynamics. Biochemical study demonstrated that the very C-terminal
Fei Xiao, Jingwei Weng, Kangnian Fan, Wenning Wang   +3 more
doaj   +1 more source

Comparative Genome Analyses of Vibrio anguillarum Strains Reveal a Link with Pathogenicity Traits [PDF]

, 2017
Vibrio anguillarum is a marine bacterium that can cause vibriosis in many fish and shellfish species, leading to high mortalities and economic losses in aquaculture.
Daniel Castillo, Faxing Zhang, Lone Gram, Mathias Middelboe, Olga Zhaxybayeva, Paul D. Alvise, Ruiqi Xu   +6 more
core   +3 more sources

Protein Kinase D Intracellular Localization and Activity Control Kinase D-interacting Substrate of 220-kDa Traffic through a Postsynaptic Density-95/Discs Large/Zonula Occludens-1-binding Motif [PDF]

Journal of Biological Chemistry, 2006
Protein kinase D (PKD) controls protein traffic from the trans-Golgi network (TGN) to the plasma membrane of epithelial cells in an isoform-specific manner. However, whether the different PKD isoforms could be selectively regulating the traffic of their specific substrates remains unexplored.
Sánchez-Ruiloba, Lucía, Cabrera, Noemí, Rodríguez-Martínez, María, López-Menéndez, Celia, Higuero, Alonso M., Martín Jean-Mairet, Roberto, Iglesias, Teresa   +6 more
openaire   +3 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling [PDF]

, 2010
he Hippo pathway regulates the size of organs by controlling two opposing processes: proliferation and apoptosis. YAP2 (Yes kinase-associated protein 2), one of the three isoforms of YAP, is a WW domain-containing transcriptional co-activator that acts ...
Bader, Gary D, Boucherie, Ciska, Gettemans, Jan, Gfeller, David, Meerschaert, Kris, Oka, Tsutomu, Remue, Eline, Sidhu, Sachdev S, Sudol, Marius, Vandekerckhove, Joël, Vanloo, Berlinda   +10 more
core   +2 more sources

Inhalational Anesthetics Disrupt Postsynaptic Density Protein-95, Drosophila Disc Large Tumor Suppressor, and Zonula Occludens-1 Domain Protein Interactions Critical to Action of Several Excitatory Receptor Channels Related to Anesthesia [PDF]

Anesthesiology, 2015
AbstractAbstractHalothane and isoflurane disrupted PDZ domain–mediated interactions between potassium channel Kv1.4 and GluA2 subunit of AMPA receptor with their respective binding partners. Neither agent affected binding of γ-aminobutyric acid type B receptors with their binding partners.
Feng, Tao, Qiang, Chen, Yuko, Sato, John, Skinner, Pei, Tang, Roger A, Johns   +5 more
openaire   +2 more sources

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Neuroprotective effects of ulinastatin on Escherichia coli meningitis rats through inhibiting PKCα phosphorylation and reducing zonula occludens-1 degradation

Scientific Reports
Ulinastatin, a broad-spectrum inflammatory inhibitor widely employed in the management of severe pancreatitis and sepsis, has not been extensively investigated for its therapeutic potential in bacterial meningitis.
Xiaolan Zheng, Junsheng Wang, Huihong Su, Lingling Wu, Yan Zhang, Qianqian Tang, Tingting Ban, Kun Xie, Chunmiao Wei, Caimei Lin   +9 more
doaj   +1 more source

E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models

Molecular Oncology, 2022
Cell–cell and cell–matrix adhesion proteins that have been implicated in colorectal epithelial integrity and epithelial‐to‐mesenchymal transition could be robust prognostic and potential predictive biomarkers for standard and novel therapies. We analyzed
Jarle Bruun, Peter W. Eide, Christian Holst Bergsland, Oscar Bruck, Aud Svindland, Mariliina Arjama, Katja Välimäki, Merete Bjørnslett, Marianne G. Guren, Olli Kallioniemi, Arild Nesbakken, Ragnhild A. Lothe, Teijo Pellinen   +12 more
doaj   +1 more source

The kidney tight junction [PDF]

, 2014
The tight junction is an important subcellular organelle which plays a vital role in epithelial barrier function. Claudin, as the integral membrane component of tight junctions, creates a paracellular transport pathway for various ions to be reabsorbed ...
Hou, Jianghui
core   +2 more sources