Results 111 to 120 of about 21,719 (253)

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

The intestinal zonula occludens toxin (ZOT) receptor recognises non-native ZOT conformers and localises to the intercellular contacts

, 2003
A preliminary structural analysis of Vibrio cholerae zonula occludens toxin (ZOT) was made by equilibrium denaturation and circular dichroism. ZOT is a structurally unstable protein in aqueous solution (ΔG(H2O) 3.82 kcal/mol), the putative intra- and ...
Alvin Lee, Christopher F van der Walle, Natalie White, Lee, Alvin, van der Walle, Christopher F, White, Natalie   +5 more
core   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

Fluids and Barriers of the CNS
Background Blood–brain barrier (BBB) disruption is a central feature of cerebral malaria (CM), a severe complication of Plasmodium falciparum (Pf) infections.
Adnan Gopinadhan, Jason M. Hughes, Andrea L. Conroy, Chandy C. John, Scott G. Canfield, Dibyadyuti Datta   +5 more
doaj   +1 more source

The role of protein arginine methyltransferases in sickle cell‐mediated neurovascular impairments in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Sickle cell disease (SCD) is a hereditary blood disorder caused by mutation of β‐globin. In SCD, haemoglobin polymerization causes red blood cells to assume a rigid sickle‐shape leading to neurovascular alterations, including development of vascular dementia – characterized by cognitive impairment and reduced cerebral perfusion ...
Julia Zaccarelli‐Magalhães, Mariana Sayuri Berto Udo, Drew James Smith, Julia Langman, Luiz Henrique Matuguma, Guilherme Nagamine Gomes, Peter Rodriguez, Ammar Husan, Quanguang Zhang, Christopher G. Kevil, Cristiane Teresinha Citadin, Hung Wen Lin   +11 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Abnormal development of gastrointestinal system of homozygous Foxp2(R552H)-mutated mice

Communications Biology
Forkhead box protein P2 (Foxp2) regulates the expression of genes related to organ morphogenesis. Homozygous Foxp2(R552H) knock-in (Foxp2 R552H/R552H) mice exhibit abnormal brain development, and die around the weaning period.
Eriko Fujita-Jimbo, Sachie Nakamura, Katsuko Sudo, Takashi Momoi   +3 more
doaj   +1 more source

Sunite sheep tail fat alleviates ulcerative colitis by regulating intestinal flora and metabolites to activate PPAR signaling pathway

Journal of Agriculture and Food Research
Ulcerative colitis (UC) is a topic of great concern, and there are no effective medications to treat it. Previous studies have shown that dietary adjustment may alleviate UC.
Jinhua Baoyindugurong, Pufang Liu, Chenchen Feng, Dan Chen, Lixing Wang, Jiletu Huge, Ronglun Hou, Yawen Li, Xinlei Yan   +8 more
doaj   +1 more source

Protein Kinase C-ε Promotes EMT in Breast Cancer

Breast Cancer: Basic and Clinical Research, 2014
Protein kinase C (PKC), a family of serine/threonine kinases, plays critical roles in signal transduction and cell regulation. PKCε, a member of the novel PKC family, is known to be a transforming oncogene and a tumor biomarker for aggressive breast ...
Kirti Jain, Alakananda Basu
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source