Results 121 to 130 of about 21,719 (253)

Structure-­‐function analysis of the C-­‐terminal domain, ZU5, of the Zonula Occludens-­‐1 protein

, 2011
Zonula occludens--‐1 (ZO--‐1) is a large scaffold protein necessary for tight junction formation and signaling. Despite extensive studies of the ZO--‐1 protein, there remains ambiguity concerning the function of the C--‐terminal ZU5 domain.
Brady, Rachel C
core  

Endodontic Treatment of Apical Periodontitis Mitigates Systemic Inflammation and Restores the Blood–Brain Barrier Integrity in an In Vitro Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim A growing body of research supports an association between periapical inflammation and an increased risk of various systemic effects. However, there is currently no scientific evidence demonstrating a causal relationship between this inflammation and changes in epithelial or endothelial permeability in patients with apical periodontitis ...
Loredana Bergandi, Mario Alovisi, Elena Tachis, Nicola Scotti, Andrea Baldi, Iris Chiara Salaroglio, Sabrina Digiovanni, Lorena Charrier, Francesca Silvagno, Damiano Pasqualini   +9 more
wiley   +1 more source

Affinity purification and partial characterization of the zonulin/zonula occludens toxin (Zot) receptor from human brain

, 2000
The intercellular tight junctions (TJs) of endothelial cells represent the limiting structure for the permeability of the blood-brain barrier (BBB). Although the BBB has been recognized as being the interface between the bloodstream and the brain, little
UZZAU, Sergio, Zielke HR, Wang W, Lu R, Vigorito R, Fasano A.   +5 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

, 2011
International audienceRecent studies suggest that blood-brain barrier (BBB) permeability contributes to epileptogenesis in symptomatic epilepsies. We have previously described angiogenesis, aberrant vascularization, and BBB alteration in drug-refractory ...
Lerner-Natoli, Mireille, M. Morin-Brureau, Fagni, Laurent, J. Bockaert, Morin-Brureau, M., F. de Bock, Rousset, M.-C., L. Fagni, de Bock, Frédéric, M. Lerner-Natoli, Bockaert, Joël, Lebrun, Aurore, A. Lebrun, M.-C. Rousset   +13 more
core   +1 more source

Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy

Journal of Ophthalmology, 2015
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR.
Jianbo He, Hong Wang, Ying Liu, Wen Li, Dorothy Kim, Hu Huang   +5 more
doaj   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Metabolic Reprogramming and GM‐CSF Secretion in Areca Nut‐Activated Fibroblasts Drive Oral Precancer Progression

Oral Diseases, EarlyView.
ABSTRACT Objective Oral cancer, with a rising global incidence and poor prognosis, is associated with areca nut use in South and Southeast Asia. In this study, we addressed the effects of areca nut extract (ANE) on oral carcinogenesis by modulating fibroblast behavior in oral tissue.
Yen‐Yun Wang, Chang‐Wei Su, Chih‐Huang Tseng, Pang‐Yu Chen, Hieu D. H. Nguyen, Leong‐Perng Chan, Yuk‐Kwan Chen, Shih Sheng Jiang, Steven Lo, Shyng‐Shiou F. Yuan   +9 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Loss of Zonula Occludens-1 (ZO-1) Enhances Angiogenic Signaling in Ovarian Cancer Cells

Zonula occludens-1 (ZO-1), encoded by the TJP1 gene, is a crucial scaffolding protein within tight junctions that maintains epithelial and endothelial barrier integrity.
Heungyeol Kim, Ki Hyung Kim, Min-Hye Kim, Hongbae Kim, Hee-Jae Cha, Ji Young Lee, Wan Kyu Eo, Seongsoo Choi, Do-Ye Kim, HyoJin An   +9 more
core   +1 more source