Results 101 to 110 of about 29,405 (257)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

CD24 regulated gene expression and distribution of tight junction proteins is associated with altered barrier function in oral epithelial monolayers

BMC Cell Biology, 2009
Background Control of intercellular penetration of microbial products is critical for the barrier function of oral epithelia. We demonstrated that CD24 is selectively and strongly expressed in the cells of the epithelial attachment to the tooth and the ...
Simonian Mary, Nadkarni Mangala A, Ye Ping, Hunter Neil   +3 more
doaj   +1 more source

A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function. [PDF]

, 2019
Intestinal epithelial cell (IEC) junctions constitute a robust barrier to invasion by viruses, bacteria and exposure to ingested agents. Previous studies showed that microgravity compromises the human immune system and increases enteropathogen virulence.
Alvarez, Rocio, Marchelletta, Ronald R, McCole, Declan F, Prisk, G Kim, Sayoc-Becerra, Anica, Stork, Cheryl A   +5 more
core   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Effects of tryptophan supplementation on performance, intestinal morphology and protein abundance of tight junction protein and indoleamine 2, 3-dioxygenase in weaned pigs

Czech Journal of Animal Science
This study determined the effect of tryptophan (Trp) supplementation on the protein abundance of intestinal tight junction and indoleamine 2, 3-dioxygenase (IDO) in weaned pigs.
Pei Mao, Naizhi Hu, Mengmeng Gao, Lingping Zhao, Chengsheng Song, Wenfeng Ma   +5 more
doaj   +1 more source

Diversity in protein–protein interactions of connexins: emerging roles [PDF]

, 2004
Gap junctions, specialised membrane structures that mediate cell-to-cell communication in almost all tissues, are composed of channel-forming integral membrane proteins termed connexins.
Duffy, Thomas, Levitan, Aasland, Harris, White, Bruzzone, Kwak, Ahmad, Liu, Morley, Homma, Zhou, Revilla, Peracchia, Moreno, Duffy, Hoshi, Stergiopoulos, Anumonwo, Songyang, Nourry, Fanning, Saimi, Peracchia, Van Eldik, Török, Sotkis, Gonzalez-Mariscal, Kausalya, Laing, Guerrier, Barker, Barker, Toyofuku, Wu, Day, Kojima, Defamie, Giepmans, Luque, Toyofuku, Doyle, Toyofuku, Laing, Kojima, Kojima, Nielsen, Nielsen, Nielsen, Nagaoka, Nusrat, Ai, Xu, Fujimoto, Nagafuchi, Singh, Gutstein, Meyer, Kostin, Jongen, Hernandez-Blazquez, Swenson, Loo, Warn-Cramer, Kanemitsu, Giepmans, Doble, Bowling, Schulz, Cooper, Mussini, Schiavon, Cooper, Giepmans, Giepmans, Murray, Thomas, Lo, Yamane, Butkevich, Schubert, Naus, Huang, Ciechanover, Pickart, Hicke, Laing, Hülser, Rutz, Jin, Jin, Thalmann, Wang, Gupta, McLeod, Rodina, Kay, Calero, TenBroek, Martin, Mitic, Fishman, Dunham, Martin, Lauf, Johnson, Govindarajan, Johnson, Frenzel, Hertig, Anderson, Laing, Thomas, Goldberg, Guan, Guo, Beardslee, Woodward, Prowse, Wang, Hsu, Verrecchia, Noma, Cruciani, TenBroek, Hossain, Hossain, Duthe, van Veen, Traub, Kwak, Li, Shiokawa-Sawada, Warn-Cramer, Bukauskas, Jugloff, Koval, Goldberg, Theiss, Yamane, Cotrina, Cotrina, Plotkin, Duffy, Itoh, Mitic, Sheng, Davis, Giepmans   +149 more
core   +1 more source

Connexin 36 is expressed and associated with zonula occludens-1 protein in PC-12 cells.

General physiology and biophysics, 2007
Connexin 36 (Cx36) is the predominant connexin isoform expressed in the mammalian neurons of the central nervous system (CNS). PC-12 cells, a neuronal-like cell line, are widely used for neuron functional studies. Many connexins have been shown to interact with zonula occludens-1 protein (ZO-1), a tight junction associated with protein.
S J, Lu, H, Li, F H, Zhou, J J, Zhang, L X, Wang   +4 more
openaire   +1 more source

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Bitter Melon Polysaccharides Enhance Goblet Cell Function and Mucosal Integrity in DSS‐Induced Colitis Through Microbiota Remodeling

Food Bioengineering, EarlyView.
ABSTRACT Bitter melon polysaccharides (BMPs), a key bioactive component of bitter melon, exhibit a range of biological activities including gut microbiota regulation, immune modulation, and antioxidant activity. Based on previous evidence of its protective effect on the colonic mucus barrier under high‐fat‐diet condition, this study evaluated the ...
Tangying Kang, Yiming Zhu, Jiaxuan Zhu, Meiling Xiao, Yansheng Zhao, Ying Zhu, Xiang Xiao   +6 more
wiley   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source