Results 41 to 50 of about 25,883 (139)

Tear fluid levels of interleukin-6 and tight junction protein ZO-1 and their association with the course of bacterial keratitis in type 2 diabetes mellitus under martial law in Ukraine

Медична наука України
Relevance. Bacterial keratitis is one of the most common infectious diseases of the cornea and may lead to severe complications, persistent visual impairment, and disability. Aim.
Andrii Hudz, Solomiia Kadubets
doaj   +1 more source

Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model

Burns & Trauma, 2019
Background The intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade ...
Yajun Song, Yang Li, Ya Xiao, Wengang Hu, Xu Wang, Pei Wang, Xiaorong Zhang, Jiacai Yang, Yong Huang, Weifeng He, Chibing Huang   +10 more
doaj   +1 more source

Differential expression and localization of tight junction proteins in the goat epididymis

Journal of Animal Science and Technology, 2022
The blood-epididymis barrier (BEB) forms a unique microenvironment that is crucial for the maturation, protection, transport, and storage of spermatozoa in the epididymis.
Sung Woo Kim, Yu-Da Jeong, Ga-Yeong Lee, Jinwook Lee, Jae-Yeung Lee, Chan-Lan Kim, Yeoung-Gyu Ko, Sung-Soo Lee, Bongki Kim   +8 more
doaj   +1 more source

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

Biomolecules, 2021
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial ...
Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie   +3 more
doaj   +1 more source

Effects of interleukin-13 and montelukast on the expression of zonula occludens-1 in human podocytes. [PDF]

Yonsei Med J, 2015
PURPOSE: The aim of this study was to investigate whether pathologic changes in zonula occludens-1 (ZO-1) are induced by interleukin-13 (IL-13) in the experimental minimal-change nephrotic syndrome (MCNS) model and to determine whether montelukast, a ...
Park SJ, Saleem MA, Nam JA, Ha TS, Shin JI.   +4 more
europepmc   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Moderate Reduction in Dietary Net Energy Level Enhances Intestinal Health in Tunchang Pigs via Gut Microbiota Modulation

Animals
To investigate the effects of low net-energy (NE) diets on intestinal health in Tunchang pigs, 96 animals (25.40 ± 1.11 kg) were randomly assigned to four dietary treatment groups with NE levels of 9.82 (CG), 9.57 (EY1), 9.32 (EY2), and 9.07 (EY3) MJ/kg.
Xilong Yu, Hongzhi Wu, Haoliang Chai, Dexin Zhao, Weiqi Peng, Fengjie Ji, Lidong Zhang, Renlong Lv   +7 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source