Results 61 to 70 of about 31,457 (207)

Two‐Photon Polymerized Microvascular Environments for Multicellular Modeling of the Blood–Brain Tumor Barrier

Advanced Materials Technologies, EarlyView.
Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin, Sayba Z. Chowdhury, Maurice de Wit, Rania Head, Kiki Bals, Erwin Brosens, Marvin M. van Luijn, Hayri E. Balcioglu, Angelo Accardo, Pim J. French   +9 more
wiley   +1 more source

Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome

Journal of Translational Medicine, 2023
Background Preclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects and clinical trials are ongoing to assess its impact on major clinical outcomes in patients with ARDS ...
Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire, Cécile Saint-Béat, Camille Theilliere, Corinne Belville, Randy Coupet, Raiko Blondonnet, Damien Bouvier, Loic Blanchon, Vincent Sapin, Matthieu Jabaudon   +11 more
doaj   +1 more source

Zonula Occludens-1, Occludin, and E-cadherin Protein Expression in Biliary Tract Cancers

Pathology & Oncology Research, 2009
The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin.
Németh, Zsuzsanna, Szász, Attila Marcell, Somorácz, Áron, Tátrai, Péter, Németh, J., Győrffy, Hajnalka, Szijártó, Attila, Kupcsulik, Péter, Kiss, András, Schaff, Zsuzsa   +9 more
openaire   +3 more sources

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

TAZ interacts with zonula occludens‐1 and ‐2 proteins in a PDZ‐1 dependent manner

FEBS Letters, 2010
MINT‐7994937: ZO‐2 (uniprotkb:Q95168) binds (MI:0407) to TAZ (uniprotkb:Q9EPK5) by pull down (MI:0096) MINT‐7994900, MINT‐7994835, MINT‐7994885: ZO‐1 (uniprotkb:Q07157) physically interacts (MI:0915) with TAZ (uniprotkb:Q9EPK5) by pull down (MI:0096) MINT‐7995020: ZO‐2 (uniprotkb:Q9UDY2) and TAZ (uniprotkb:Q9GZV5) colocalize (MI:0403) by fluorescence ...
Remue, Eline, Meerschaert, Kris, Oka, Tsutomu, Boucherie, Ciska, Vandekerckhove, Joël, Sudol, Marius, Gettemans, Jan   +6 more
openaire   +2 more sources

Zonula Occludens-1 Alters Connexin43 Gap Junction Size and Organization by Influencing Channel Accretion [PDF]

Molecular Biology of the Cell, 2005
Regulation of gap junction (GJ) organization is critical for proper function of excitable tissues such as heart and brain, yet mechanisms that govern the dynamic patterning of GJs remain poorly defined. Here, we show that zonula occludens (ZO)-1 localizes preferentially to the periphery of connexin43 (Cx43) GJ plaques.
Andrew W, Hunter, Ralph J, Barker, Ching, Zhu, Robert G, Gourdie   +3 more
openaire   +2 more sources

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. [PDF]

, 2020
Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Choi, Julie, Ear, Jason, Ghassemian, Majid, Ghosh, Pradipta, Kufareva, Irina, Rajapakse, Navin, Saklecha, Anokhi   +6 more
core  

AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions [PDF]

, 2014
Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (C×36) is the most abundant isoform; however, the mechanisms underlying formation of C×36-containing electrical synapses ...
Abd-El-Barr, Anderson, Bloomfield, Chai, Christie, Ciolofan, Deans, Dedek, Demb, Dong, Dunn, Feigenspan, Flores, Güldenagel, Han, Helbig, Hilgen, Hormuzdi, Kolb, Kothmann, Kranz, Kumar, Li, Li, Li, Li, Li, Lin, Lynn, Maxeiner, Mills, Münch, Pan, Plantard, Rash, Rice, Schubert, Shelley, Strettoi, Söhl, Vaney, Veruki, Wachtmeister, Weymouth, Yu   +44 more
core   +6 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source