Results 71 to 80 of about 31,558 (238)

Tight junction protein ZO-1 in Kawasaki disease

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +1 more source

Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. [PDF]

, 2020
Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Choi, Julie, Ear, Jason, Ghassemian, Majid, Ghosh, Pradipta, Kufareva, Irina, Rajapakse, Navin, Saklecha, Anokhi   +6 more
core  

AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions [PDF]

, 2014
Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (C×36) is the most abundant isoform; however, the mechanisms underlying formation of C×36-containing electrical synapses ...
Abd-El-Barr, Anderson, Bloomfield, Chai, Christie, Ciolofan, Deans, Dedek, Demb, Dong, Dunn, Feigenspan, Flores, Güldenagel, Han, Helbig, Hilgen, Hormuzdi, Kolb, Kothmann, Kranz, Kumar, Li, Li, Li, Li, Li, Lin, Lynn, Maxeiner, Mills, Münch, Pan, Plantard, Rash, Rice, Schubert, Shelley, Strettoi, Söhl, Vaney, Veruki, Wachtmeister, Weymouth, Yu   +44 more
core   +6 more sources

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

Molecular Biology of the Cell, 2011
Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form from docking of paired connexons, with one each contributed by apposing cells.
Rhett, J. Matthew, Jourdan, L. Jane, Gourdie, Robert G.   +2 more
openaire   +3 more sources

INVESTİGATİON OF ZONULA OCCLUDENS-1 PROTEİN LEVEL İN RECTUM TİSSUE AFTER RADİOTHERAPY

International Journal of Research -GRANTHAALAYAH, 2020
The transmembrane protein zonula occludens of rectal tissue has function to prevents the spread of bacterial toxins into the intestinal mucosa and to systemic circulation. But radiotherapy causes ablation of crypt cell proliferation, mitotic catastrophe, and apoptosis leading to gastrointestinal mucositis.
Cengiz Kurtman, Esra Gümüştepe, Serdağ Demirören, Fatma Firat, Şaban Çakır Gökçe, Kemal Özbilgin   +5 more
openaire   +2 more sources

The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain [PDF]

Cellular and Molecular Life Sciences, 2009
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical ...
Kris, Meerschaert, Moe Phyu, Tun, Eline, Remue, Ariane, De Ganck, Ciska, Boucherie, Berlinda, Vanloo, Gisèle, Degeest, Joël, Vandekerckhove, Pascale, Zimmermann, Nitin, Bhardwaj, Hui, Lu, Wonhwa, Cho, Jan, Gettemans   +12 more
openaire   +2 more sources

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Foreword [PDF]

, 1941
The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common proteinprotein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found
Aarts, Bach, Bach, Bach, Bach, Bach, Bhattacharya, Chang, Charbonnier, Chen, Chi, Chi, Chi, Chi, Clarkson, Clarkson, Clausen, Cook, DeLano, Dhulesia, Doyle, El-Amraoui, Feng, Feng, Fodor, Fouassier, Fry, Fuentes, Fuentes, Fujii, Fujii, Fujii, Gallardo, Gerek, Gianni, Gianni, Goult, Grandy, Grembecka, Hajduk, Hammond, Haq, Haq, Harris, Hasselblatt, Hillier, Ho, Horovitz, Im, Ivarsson, Ivarsson, Jackson, Jemth, Joshi, Kachel, Kaneko, Karlsson, Kennedy, Kong, Law, LeBlanc, Lee, Lee, Lim, Liu, Liu, Lockless, Long, Mayasundari, Niu, Nomme, Nourry, Opazo, Pan, Pan, Patra, Peterson, Petit, Piserchio, Sainlos, Sakarya, Saro, Saupe, Shan, Shan, Shan, Skelton, Staneva, Stiffler, Subbaiah, Te Velthuis, Thorsen, Thorsen, Tochio, Udugamasooriya, van den Berk, von Ossowski, Walma, Wang, Wang, Wawrzyniak, Wells, Wiedemann, Wilken, Zhang, Zhang, Zhang, Zhang, Zimmermann   +108 more
core   +3 more sources

Membrane-Type 1 Matrix Metalloproteinase Expression Is Regulated by Zonula Occludens-1 in Human Breast Cancer Cells [PDF]

Cancer Research, 2005
Abstract The acquisition of a migratory/invasive phenotype by tumor cells is characterized by the loss of cell-cell adhesion contacts and the expression of degradative properties. In this study, we examined the effect of the disorganization of occludin/zonula occludens (ZO)-1 tight junction (TJ) complexes on the expression of membrane ...
Polette, Myriam, Gilles, Christine, Nawrocki-Raby, Béatrice, Lohi, Jouko, Hunziker, Walter, Foidart, Jean-Michel, Birembaut, Philippe, L.   +6 more
openaire   +5 more sources

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source