A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons [PDF]
Frontiers in PharmacologyIntroductionDysfunction of axoplasmic transport is closely linked to depression. Baicalin, a major flavonoid in Scutellaria baicalensis, a well-known traditional Chinese medicine used in depression treatment, has demonstrated antidepressant-like effects ...
Shuaifei Lu +19 more
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Advances in origin, evolution, and pathogenesis of optic disc drusen: A narrative review [PDF]
Indian Journal of OphthalmologyOptic disc drusen (ODD) is acellular calcified deposits found mainly in front of the lamina cribrosa within the optic nerve. It can cause chronic or acute vision loss.
Xiyuan Liu, Yan Yan
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Slow axoplasmic transport under scrutiny [PDF]
Biological Research, 2011 The origin of axoplasmic proteins is central for the biology of axons. For over fifty years axons have been considered unable to synthesize proteins and that cell bodies supply them with proteins by a slow transport mechanism.
Felipe A Court, Jaime Álvarez
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Real time monitoring peripheral nerve function with ICG and BDA-ICG by NIR-II fluorescence imaging [PDF]
Materials Today BioNeuroanatomical tract tracers are important for studying axoplasmic transport and the complex interconnections of the nervous system. Though traditional fluorescent tracers are widely used, they have several prominent drawbacks when imaging, including ...
Xiaoqi Yang +10 more
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What is axoplasmic transport? Considering the role of exercise training: A mini review [PDF]
Journal of Exercise & Organ Cross Talk, 2022 Like other cells in the body, nerve cells need many proteins and substances to maintain homeostasis. As we know, the transcription and translation of proteins and necessary cellular substances occurs in the cell nucleus.
Hasti Sherizadeh
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Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration
eLife, 2022 Many neurons in the adult central nervous system, including retinal ganglion cells (RGCs), degenerate and die after injury. Early axon protein and organelle trafficking failure is a key component in many neurodegenerative disorders yet changes to ...
Sahil H Shah +14 more
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Bilateral optic neuropathy as a complication of allogeneic hematopoietic stem cell transplantation
Biomedical Papers, 2023 Background. The authors present a case study which describes the development of bilateral optic neuropathy as a complication of allogeneic hematopoietic stem cell transplantation (HSCT) in a patient who underwent a transplant for B-cell acute ...
Jan Lestak +6 more
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Diagnostic Ability of Transverse Axial Images Obtained by Optical Coherence Tomography for Detecting Anterior Displacement of Peripapillary Tissues in Papilledema. [PDF]
Clin Exp OphthalmolABSTRACT Background To evaluate the diagnostic ability of optical coherence tomography (OCT) images to detect posterior pole deformation and anterior displacement of the optic disc (ADOD) in papilledema before and after intracranial pressure reduction with medical treatment.
Barbosa GCS +5 more
europepmc +2 more sources
Maintenance and degradation of proteins in intact and severed axons: Implications for the mechanism of long-term survival of anucleate crayfish axons [PDF]
, 1995 Protein maintenance and degradation are examined in the severed distal (anucleate) portions of crayfish medial giant axons (MGAs), which remain viable for over 7 months following axotomy.
Bittner, George D. +2 more
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A Stochastic Compartmental Model for Fast Axonal Transport [PDF]
, 2011 In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons.
McKinley, Scott A. +2 more
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