Results 21 to 30 of about 10,586 (218)

GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction

Platelets, 2023
GALE gene encodes the uridine diphosphate [UDP]-galactose-4-epimerase, which catalyzes the bidirectional interconversion of UDP-glucose to UDP-galactose, and UDP-N-acetyl-glucosamine to UDP-N-acetyl-galactosamine.
Ana Marín-Quílez, Christian A. Di Buduo, Rocío Benito, Alessandra Balduini, José Rivera, Jose Maria Bastida   +5 more
doaj   +1 more source

Cloning, Expression and Characterization of UDP-Glucose Dehydrogenases

Life, 2021
Uridine diphosphate-glucose dehydrogenase (UGD) is an enzyme that produces uridine diphosphate-glucuronic acid (UDP-GlcA), which is an intermediate in glycosaminoglycans (GAGs) production pathways.
Márcia R. Couto, Joana L. Rodrigues, Lígia R. Rodrigues   +2 more
doaj   +1 more source

Immobilization of the Highly Active UDP-Glucose Pyrophosphorylase From Thermocrispum agreste Provides a Highly Efficient Biocatalyst for the Production of UDP-Glucose

Frontiers in Bioengineering and Biotechnology, 2020
Biocatalysis that produces economically interesting compounds can be carried out by using free enzymes or microbial cells. However, often the cell metabolism does not allow the overproduction or secretion of activated sugars and thus downstream ...
Antje Kumpf, Antje Kumpf, Antje Kumpf, Daria Kowalczykiewicz, Daria Kowalczykiewicz, Katarzyna Szymańska, Maria Mehnert, Isabel Bento, Aleksandra Łochowicz, André Pollender, Andrzej Jarzȩbski, Andrzej Jarzȩbski, Dirk Tischler   +12 more
doaj   +1 more source

Uridine Diphosphate Glucose: the Coenzyme of the Galactose–Glucose Phosphate Isomerization [PDF]

Nature, 1950
A PREVIOUS report1 dealt with the enzymatic conversion of galactose-1-phosphate into glucose-1-phosphate and mentioned that a thermostable factor is necessary for the reaction. This factor has now been obtained practically pure, and for reasons given below will be referred to as uridine diphosphate glucose.
Cardini, Carlos E., Paladini, Alejandro C., Caputto, Ranwel, Leloir, Luis Federico   +3 more
openaire   +3 more sources

In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids

Molecules, 2013
Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. The mortality associated with these diseases is largely due to fragile healthcare systems, lack of access to medicines, and resistance by
Ifedayo Victor Ogungbe, William N. Setzer   +1 more
doaj   +1 more source

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +1 more source

Transcriptome profiling in Salix matsudana during refilling xylem vessels after embolism

Biologia Plantarum, 2019
The objective of this study is to understand the role of bark water uptake in refilling of xylem vessels after embolism in Salix matsudana. Further, we determined expression of genes closely related to xylem embolism repair.
Y.C. Yu, J.X. Liu, Z.Y. Sun
doaj   +1 more source

CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function

mBio, 2023
Invasive aspergillosis is one of the most serious clinical invasive fungal infections, resulting in a high case fatality rate among immunocompromised patients.
Xu Han, Cecilia D'Angelo, Ainara Otamendi, Javier O. Cifuente, Elisa de Astigarraga, Borja Ochoa-Lizarralde, Martin Grininger, Francoise H. Routier, Marcelo E. Guerin, Jana Fuehring, Oier Etxebeste, Sean R. Connell   +11 more
doaj   +1 more source

Rhamnose-Containing Compounds: Biosynthesis and Applications

Molecules, 2022
Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy.
Siqiang Li, Fujia Chen, Yun Li, Lizhen Wang, Hongyan Li, Guofeng Gu, Enzhong Li   +6 more
doaj   +1 more source

YvcK, a protein required for cell wall integrity and optimal carbon source utilization, binds uridine diphosphate-sugars

Scientific Reports, 2017
In Bacillus subtilis, Listeria monocytogenes and in two Mycobacteria, it was previously shown that yvcK is a gene required for normal cell shape, for optimal carbon source utilization and for virulence of pathogenic bacteria.
Elodie Foulquier, Anne Galinier
doaj   +1 more source