Results 21 to 30 of about 18,741 (211)

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +1 more source

Cloning cDNA and functional characterization of UDP-glucose pyrophosphorylase in Dendrobium officinale

Biologia Plantarum, 2017
Dendrobium officinale is a traditional Chinese medicinal herb that produces promising bioactive polysaccharides. However, the biosynthetic pathway of polysaccharides in this herb remains to be elucidated. The uridine diphosphate glucose pyrophosphorylase
R.-L. Wan, J. Sun, T. He, Y.-D. Hu, Y. Zhao, Y. Wu, Z. Chun   +6 more
doaj   +1 more source

GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction

Platelets, 2023
GALE gene encodes the uridine diphosphate [UDP]-galactose-4-epimerase, which catalyzes the bidirectional interconversion of UDP-glucose to UDP-galactose, and UDP-N-acetyl-glucosamine to UDP-N-acetyl-galactosamine.
Ana Marín-Quílez, Christian A. Di Buduo, Rocío Benito, Alessandra Balduini, José Rivera, Jose Maria Bastida   +5 more
doaj   +1 more source

Cloning, Expression and Characterization of UDP-Glucose Dehydrogenases

Life, 2021
Uridine diphosphate-glucose dehydrogenase (UGD) is an enzyme that produces uridine diphosphate-glucuronic acid (UDP-GlcA), which is an intermediate in glycosaminoglycans (GAGs) production pathways.
Márcia R. Couto, Joana L. Rodrigues, Lígia R. Rodrigues   +2 more
doaj   +1 more source

Starch and Oligosaccharide Synthesis from Uridine Diphosphate Glucose

Journal of Biological Chemistry, 1961
Luis F. Leloir, M. A. R. de Fekete, Carlos E. Cardini   +2 more
openalex   +2 more sources

Immobilization of the Highly Active UDP-Glucose Pyrophosphorylase From Thermocrispum agreste Provides a Highly Efficient Biocatalyst for the Production of UDP-Glucose

Frontiers in Bioengineering and Biotechnology, 2020
Biocatalysis that produces economically interesting compounds can be carried out by using free enzymes or microbial cells. However, often the cell metabolism does not allow the overproduction or secretion of activated sugars and thus downstream ...
Antje Kumpf, Antje Kumpf, Antje Kumpf, Daria Kowalczykiewicz, Daria Kowalczykiewicz, Katarzyna Szymańska, Maria Mehnert, Isabel Bento, Aleksandra Łochowicz, André Pollender, Andrzej Jarzȩbski, Andrzej Jarzȩbski, Dirk Tischler   +12 more
doaj   +1 more source

In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids

Molecules, 2013
Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. The mortality associated with these diseases is largely due to fragile healthcare systems, lack of access to medicines, and resistance by
Ifedayo Victor Ogungbe, William N. Setzer   +1 more
doaj   +1 more source

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +1 more source

CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function

mBio, 2023
Invasive aspergillosis is one of the most serious clinical invasive fungal infections, resulting in a high case fatality rate among immunocompromised patients.
Xu Han, Cecilia D'Angelo, Ainara Otamendi, Javier O. Cifuente, Elisa de Astigarraga, Borja Ochoa-Lizarralde, Martin Grininger, Francoise H. Routier, Marcelo E. Guerin, Jana Fuehring, Oier Etxebeste, Sean R. Connell   +11 more
doaj   +1 more source

Transcriptome profiling in Salix matsudana during refilling xylem vessels after embolism

Biologia Plantarum, 2019
The objective of this study is to understand the role of bark water uptake in refilling of xylem vessels after embolism in Salix matsudana. Further, we determined expression of genes closely related to xylem embolism repair.
Y.C. Yu, J.X. Liu, Z.Y. Sun
doaj   +1 more source