Results 21 to 30 of about 346,735 (264)
Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells [PDF]
Frontiers in ImmunologyBackgroundInterleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal mediator of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, critically involved in innate immune activation and pro-inflammatory cytokine production ...
Sadiq Umar +4 more
doaj +2 more sources
The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review
AntioxidantsXanthine oxidoreductase (XOR) is an enzyme involved in the oxidation of hypoxanthine and xanthine to uric acid. XOR has two isoforms: xanthine dehydrogenase and xanthine oxidase (XO).
Lorenzo Annesi +3 more
doaj +2 more sources
Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma. [PDF]
Oncogenesis, 2017 Xanthine dehydrogenase (XDH), a rate-limiting enzyme involved in purine metabolism, has an essential role in inflammatory cascades. Researchers have known for decades that XDH activity is decreased in some cancers, including hepatocellular carcinoma (HCC)
Chen GL +6 more
europepmc +2 more sources
Xanthine dehydrogenase: An old enzyme with new knowledge and prospects. [PDF]
Bioengineered, 2016 Xanthine dehydrogenase (EC 1.17.1.4, XDH) is a typical and complex molybdenum-containing flavoprotein which has been extensively studied for over 110 years.
Wang CH, Zhang C, Xing XH.
europepmc +2 more sources
A case of xanthinuria type I with a novel mutation in xanthine dehydrogenase. [PDF]
CEN Case Rep, 2016 Iguchi A +8 more
europepmc +2 more sources
The Plant Genome, 2021 De novo purine biosynthesis is required for the incorporation of fixed nitrogen in ureide exporting nodules, as formed on soybean [Glycine max (L.) Merr.] roots. However, in many cases, the enzymes involved in this pathway have been deduced strictly from
Cuong X Nguyen +5 more
semanticscholar +1 more source
A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses
Crop Journal, 2022 Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine.
Jiangmin Xu +11 more
doaj +1 more source
Journal of Medicinal Chemistry, 2021 Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays an important role in one-carbon metabolism. The MTHFD2 gene is upregulated in various cancers but very low or undetectable in normal proliferating cells, and therefore a potential target for cancer
Lung-Chun Lee +10 more
semanticscholar +1 more source