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Current Biology, 2003 What are ATM and ATR? Ataxia telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) are members of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases (PIKKs). These large proteins – predicted molecular masses for ATM and ATR are 351kDa and 301kDa, respectively – are involved in cellular responses to DNA damage.Don't ...
Bradbury, Jane M., Jackson, Stephen P.
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ATR activation is regulated by dimerization of ATR activating proteins [PDF]
Journal of Biological Chemistry, 2021 The checkpoint kinase ATR regulates DNA repair, cell cycle progression, and other DNA damage and replication stress responses. ATR signaling is stimulated by an ATR activating protein, and in metazoan cells, there are at least two ATR activators: TOPBP1 and ETAA1.
Vaughn Thada, David Cortez
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Cell Cycle, 2006 ATR is a critical upstream regulator of checkpoint responses to incompletely replicated and damaged DNA. However, it had not been understood how the kinase activity of ATR is switched on during checkpoint responses. TopBP1 and its homologs are necessary for both DNA replication and checkpoint control.
Akiko, Kumagai, William G, Dunphy
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Cell, 2006 The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR ...
Bartek, Jiri, Mailand, Niels
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Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA [PDF]
Nature Communications, 2018 AbstractATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from ATR loss. Mouse model expressing kinase-dead ATR (Atr+/KD), but not loss of ATR (Atr+/−), displays ssDNA-dependent defects at the non-homologous region of X-Y chromosomes during male meiosis ...
Demis Menolfi +8 more
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Zeolite coated ATR crystals for new applications in FTIR-ATR spectroscopy
Chemical Communications, 2004 Thin silicalite-1 films were grown on ATR crystals and used for detection of low amounts of organic molecules in a gas flow by FTIR spectroscopy.
Wang, Zeng +4 more
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Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism
iScience, 2020 Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a potential link between ATR inhibition and the autophagy process in esophageal cancer cells using four ATR inhibitors including two in clinical testing.
Elizabeth Bowler +10 more
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ATR Schritt 5: Texterkennung und Post-ATR-Korrektur
von Floriane Chiffoleau und Sarah Ondraszek Read this blog post in English on DARIAH-Campus: https://hdl.handle.net/21.11159/019595c5-10bc-76da-97f2-08c40c70432e Lire la version française de cet article : https://harmoniseatr.hypotheses.org/2866 https://youtu.be/P5O8bPR9hXg Dieser Artikel führt Sie in die Welt der automatischen Texterkennung (ATR) und ...
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