Bridging a Gap in SAR-ATR: Training on Fully Synthetic and Testing on Measured Data
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021 Obtaining measured synthetic aperture radar (SAR) data for training automatic target recognition (ATR) models can be too expensive (in terms of time and money) and complex of a process in many situations.
Nathan Inkawhich +6 more
semanticscholar +1 more source
Claspin and the Activated Form of ATR-ATRIP Collaborate in the Activation of Chk1 [PDF]
, 2004 Claspin is necessary for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated DNA. ATR possesses a regulatory partner called ATRIP. We have studied the respective roles of ATR-ATRIP and Claspin in the activation
Dunphy, William G. +2 more
core +1 more source
Nature Communications, 2020 Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by increased ATR-CHK1 activity and sensitivity to ATR inhibition (ATRi). However, PARPi-
Hyoung Kim +20 more
semanticscholar +1 more source
Progress towards a clinically-successful ATR inhibitor for cancer therapy
Current Research in Pharmacology and Drug Discovery, 2021 The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated ...
Francis M Barnieh +2 more
semanticscholar +1 more source
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR [PDF]
, 2007 TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA. This process involves binding of ATR to the ATR-activating domain of TopBP1, which is located between BRCT domains VI and VII ...
Dunphy, William G. +2 more
core +2 more sources
ATR Inhibition Induces CDK1–SPOP Signaling and Enhances Anti–PD-L1 Cytotoxicity in Prostate Cancer
Clinical Cancer Research, 2021 Purpose: Despite significant benefit for other cancer subtypes, immune checkpoint blockade (ICB) therapy has not yet been shown to significantly improve outcomes for men with castration-resistant prostate cancer (CRPC).
Zhe Tang +13 more
semanticscholar +1 more source
A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]
, 2018 The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria +11 more
core +2 more sources
, 2023 R scripts used in the publication for the analysis of the phospho-proteomics dataset.
Jadav, Rathan S +2 more
+7 more sources
Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]
, 2015 Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert +6 more
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Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer
Cancers, 2021 Simple Summary Selective killing of cancer cells is privileged mainstream in cancer treatment and targeted therapy represents the new tool with a potential to pursue this aim. It can also aid to overcome resistance of conventional chemo- or radio-therapy.
L. Górecki, M. Andrs, J. Korábečný
semanticscholar +1 more source