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Cell, 2006 The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR ...
Bartek, Jiri, Mailand, Niels
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Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism
iScience, 2020 Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a potential link between ATR inhibition and the autophagy process in esophageal cancer cells using four ATR inhibitors including two in clinical testing.
Elizabeth Bowler +10 more
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ATR activation is regulated by dimerization of ATR activating proteins [PDF]
Journal of Biological Chemistry, 2021 The checkpoint kinase ATR regulates DNA repair, cell cycle progression, and other DNA damage and replication stress responses. ATR signaling is stimulated by an ATR activating protein, and in metazoan cells, there are at least two ATR activators: TOPBP1 and ETAA1.
Vaughn Thada, David Cortez
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Current Biology, 2003 What are ATM and ATR? Ataxia telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) are members of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases (PIKKs). These large proteins – predicted molecular masses for ATM and ATR are 351kDa and 301kDa, respectively – are involved in cellular responses to DNA damage.Don't ...
Bradbury, Jane M., Jackson, Stephen P.
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ATR signaling at a glance [PDF]
Journal of Cell Science, 2009 The maintenance of genomic integrity is crucial for the survival of all organisms. In humans, compromised genomic integrity contributes to genetic disorders, aging and cancers. The task of safeguarding the genome is accomplished by the concerted action of a number of cellular processes ...
Bunsyo, Shiotani, Lee, Zou
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Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA [PDF]
Nature Communications, 2018 AbstractATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from ATR loss. Mouse model expressing kinase-dead ATR (Atr+/KD), but not loss of ATR (Atr+/−), displays ssDNA-dependent defects at the non-homologous region of X-Y chromosomes during male meiosis ...
Demis Menolfi +8 more
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Discriminative sparsity for Sonar ATR [PDF]
OCEANS 2015 - MTS/IEEE Washington, 2015 Advancements in Sonar image capture have enabled researchers to apply sophisticated object identification algorithms in order to locate targets of interest in images such as mines. Despite progress in this field, modern sonar automatic target recognition (ATR) approaches lack robustness to the amount of noise one would expect in real-world scenarios ...
John McKay 0002 +3 more
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, 2023 R scripts used in the publication for the analysis of the phospho-proteomics dataset.
Jadav, Rathan S +2 more
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Function of the ATR N-terminal domain revealed by an ATM/ATR chimera [PDF]
Experimental Cell Research, 2007 The ATM and ATR kinases function at the apex of checkpoint signaling pathways. These kinases share significant sequence similarity, phosphorylate many of the same substrates, and have overlapping roles in initiating cell cycle checkpoints. However, they sense DNA damage through distinct mechanisms.
Xinping, Chen +3 more
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Cell Cycle, 2006 ATR is a critical upstream regulator of checkpoint responses to incompletely replicated and damaged DNA. However, it had not been understood how the kinase activity of ATR is switched on during checkpoint responses. TopBP1 and its homologs are necessary for both DNA replication and checkpoint control.
Akiko, Kumagai, William G, Dunphy
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