Results 1 to 10 of about 406,746 (290)
ATR activation is regulated by dimerization of ATR activating proteins [PDF]
Journal of Biological Chemistry, 2021 The checkpoint kinase ATR regulates DNA repair, cell cycle progression, and other DNA damage and replication stress responses. ATR signaling is stimulated by an ATR activating protein, and in metazoan cells, there are at least two ATR activators: TOPBP1 and ETAA1.
Vaughn Thada, David Cortez
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A Comprehensive Survey on SAR ATR in Deep-Learning Era
Remote Sensing, 2023 Due to the advantages of Synthetic Aperture Radar (SAR), the study of Automatic Target Recognition (ATR) has become a hot topic. Deep learning, especially in the case of a Convolutional Neural Network (CNN), works in an end-to-end way and has powerful ...
Jianwei Li +5 more
semanticscholar +1 more source
Current Biology, 2003 What are ATM and ATR? Ataxia telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) are members of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases (PIKKs). These large proteins – predicted molecular masses for ATM and ATR are 351kDa and 301kDa, respectively – are involved in cellular responses to DNA damage.Don't ...
Bradbury, Jane M., Jackson, Stephen P.
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Carbohydrate Polymers, 2021 The contribution of ATR-FTIR spectroscopy to study cell wall polysaccharides (CWPs) was carefully investigated. The region 1800-800 cm-1 was exploited using principal component analysis and hierarchical clustering on a large range of different powders of
Xuwei Liu +3 more
semanticscholar +1 more source
Emerging strategies for cancer therapy by ATR inhibitors
Cancer Science, 2023 DNA replication stress (RS) causes genomic instability and vulnerability in cancer cells. To counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling pathway, which regulates origin firing, cell cycle checkpoints, and fork ...
K. Yano, B. Shiotani
semanticscholar +1 more source
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome [PDF]
, 2012 A homozygous mutational change in the Ataxia-Telangiectasia and RAD3 related (ATR) gene was previously reported in two related families displaying Seckel Syndrome (SS). Here, we provide the first identification of a Seckel Syndrome patient with mutations
A Ciccia +52 more
core +8 more sources
Cancer Research, 2022 This detailed preclinical investigation, including pharmacokinetics/pharmacodynamics and dose–schedule optimizations, of AZD6738/ceralasertib alone and in combination with chemotherapy or PARP inhibitors can inform ongoing clinical efforts to treat ...
Zena Wilson +11 more
semanticscholar +1 more source
In Analysis, 2022 Scientific investigation of cultural heritage objects plays a vital role in a responsible modern approach to conservation and archaeology. Recent advances in spectroscopy, such as the development of Attenuated Total Reflection Fourier Transform Infrared (
Guan-Lin Liu, S. Kazarian
semanticscholar +1 more source
ATR signaling at a glance [PDF]
Journal of Cell Science, 2009 The maintenance of genomic integrity is crucial for the survival of all organisms. In humans, compromised genomic integrity contributes to genetic disorders, aging and cancers. The task of safeguarding the genome is accomplished by the concerted action of a number of cellular processes ...
Bunsyo, Shiotani, Lee, Zou
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Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA [PDF]
Nature Communications, 2018 AbstractATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from ATR loss. Mouse model expressing kinase-dead ATR (Atr+/KD), but not loss of ATR (Atr+/−), displays ssDNA-dependent defects at the non-homologous region of X-Y chromosomes during male meiosis ...
Demis Menolfi +8 more
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