Results 21 to 30 of about 406,746 (290)

Discriminative sparsity for Sonar ATR [PDF]

OCEANS 2015 - MTS/IEEE Washington, 2015
Advancements in Sonar image capture have enabled researchers to apply sophisticated object identification algorithms in order to locate targets of interest in images such as mines. Despite progress in this field, modern sonar automatic target recognition (ATR) approaches lack robustness to the amount of noise one would expect in real-world scenarios ...
John McKay 0002, Raghu G. Raj, Vishal Monga, Jason T. Isaacs   +3 more
openaire   +2 more sources

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2020
Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is a label-free, non-destructive technique that can be applied to a vast range of biological applications, from imaging cancer tissues and live cells, to determining protein ...
Hannah Tiernan, B. Byrne, S. Kazarian
semanticscholar   +1 more source

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors

Journal of Clinical Oncology, 2020
PURPOSE Preclinical studies demonstrated that ATR inhibition can exploit synthetic lethality (eg, in cancer cells with impaired compensatory DNA damage responses through ATM loss) as monotherapy and combined with DNA-damaging drugs such as carboplatin ...
T. Yap, Brent O’Carrigan, M. Penney, J. Lim, Jessica Brown, M. J. De Miguel Luken, N. Tunariu, R. Pérez-López, D. Rodrigues, R. Riisnaes, I. Figueiredo, S. Carreira, B. Hare, K. McDermott, S. Khalique, C. Williamson, R. Natrajan, S. Pettitt, C. Lord, U. Banerji, Jack Pollard, Juanita Lopez, J. D. de Bono   +22 more
semanticscholar   +1 more source

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Molecular Cancer Therapeutics, 2021
Although several ATR inhibitors are in development, there are unresolved questions regarding their differential potency, molecular signatures of patients with cancer for predicting activity, and most effective therapeutic combinations. Here, we elucidate
U. Jo, Ilya S. Senatorov, A. Zimmermann, L. Saha, Yasuhisa Murai, Se Hyun Kim, V. Rajapakse, Fathi Elloumi, N. Takahashi, Christopher W. Schultz, Anish Thomas, F. Zenke, Y. Pommier   +12 more
semanticscholar   +1 more source

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling [PDF]

, 2007
Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling.
A Kramer, A Purohit, Anand Saggar, Andrew P Jackson, Ben Hamel, Bertrand Vernay, C Ponting, Carol-Anne Martin, CG Woods, D Chen, D Diviani, Elen Griffith, F Majewski, F Ruschendorf, GK Alderton, GK Alderton, H Dodson, H Loffler, H Niida, HPG Seckel, J Bond, J Bond, JB Dictenberg, K Miyoshi, M Martinez-Campos, M O'Driscoll, Mark O'Driscoll, MR Flory, Nouriya Al Sanna, P Brown, Paola Vagnarelli, Penny A Jeggo, Q Li, RD Martin, S Doxsey, S Sengupta, S Zhang, Sarah Walker, SJ Doxsey, Tom Stiff, WC Zimmerman, William C Earnshaw, Y Shiloh   +42 more
core   +4 more sources

Cell cycle checkpoint signaling through the ATM and ATR kinases.

Genes & Development, 2001
The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular metabolism (e.g., reactive oxygen intermediates and inaccurately replicated DNA)
R. Abraham
semanticscholar   +1 more source

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion

Cell & Bioscience, 2020
DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates a complex post-translational network termed DNA damage response (DDR).
Demis Menolfi, S. Zha
semanticscholar   +1 more source

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Schlafen-11 (SLFN11) inactivation leads to chemoresistance of a broad range of DNA-damaging agents. We uncover an expanded Ataxia Telangiectasia- and Rad3-related (ATR)-mediated signaling network that overcomes chemoresistance by an unbiased
U. Jo, Yasuhisa Murai, S. Chakka, Lu Chen, K. Cheng, J. Murai, L. Saha, L. M. Miller Jenkins, Y. Pommier   +8 more
semanticscholar   +1 more source

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

EMBO Journal, 2020
Mechanistic understanding of how ionizing radiation induces type I interferon signaling and how to amplify this signaling module should help to maximize the efficacy of radiotherapy.
Xu Feng, Anthony T. Tubbs, Chunchao Zhang, Mengfan Tang, Sriram Sridharan, Chao Wang, D. Jiang, Dan Su, Huimin Zhang, Zhen Chen, Litong Nie, Yun Xiong, Min Huang, A. Nussenzweig, Junjie Chen   +14 more
semanticscholar   +1 more source

Function of the ATR N-terminal domain revealed by an ATM/ATR chimera [PDF]

Experimental Cell Research, 2007
The ATM and ATR kinases function at the apex of checkpoint signaling pathways. These kinases share significant sequence similarity, phosphorylate many of the same substrates, and have overlapping roles in initiating cell cycle checkpoints. However, they sense DNA damage through distinct mechanisms.
Xinping, Chen, Runxiang, Zhao, Gloria G, Glick, David, Cortez   +3 more
openaire   +2 more sources