Results 61 to 70 of about 150,764 (232)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Equivalence Problem and History in Translation with Samples from the Armenian and Sanskrit Languages / ERMENİ VESANSKRİT DİLLERİNDEN ÖRNEKLERLE ÇEVİRİDE EŞDEĞERLİK SORUNU VE TARİHİ [PDF]

Folklor/Edebiyat, 2016
The concept of equivalence, which is a mathematical term, as a result of a linguistic approach took place in literature. Clarity or complexity of the relationship between the target text and source text are discussed through the equivalence concept ...
F. Jale Gül Çoruk*, Yalçın Kayalı**
doaj  

Statistical Methods for Quality Equivalence of Topical Products. 0.5 mg/g Betamethasone Ointment as a Case-Study

Pharmaceutics, 2020
This study examines the statistical implications, and their possible implementation, of the “Draft guideline on quality and equivalence of topical products” issued by the European Medicines Agency in 2018, with particular focus on the section devoted to ...
Jordi Ocaña, Toni Monleón-Getino, Virginia Merino, Daniel Peris, Lluís Soler   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Gauge equivalence problem on differential operators under fiber-preserving transformation [PDF]

Journal of Mahani Mathematical Research
This paper focuses on investigating the equivalence problem for fifth-order differential operators (FODOs) on the line under general fiber-preserving transformations.
Morteza Bakhshandeh, Rohollah Bakhshandeh Chamazkoti, Mehdi Nadjafikhah   +2 more
doaj   +1 more source

Hodge decomposition for stable homology of automorphism groups of free groups

, 2019
We establish a decomposition of stable homology of automorphism groups of free groups with polynomial contravariant coefficients in term of functor homology.
Djament, Aurélien
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Concept de service innovant et d'incitation au développement durable: étude de faisabilité d'un système d'échange implémenté au sein d'un réseau de parties prenantes [PDF]

, 2014
implémenté au sein d’un réseau de parties prenantes. En réaction à la crise financière de 2008 et après un vote unanime le 29 mai 2013 à l’Assemblée Générale d’APRÈS-GE, qui regroupe près de 250 membres, la Chambre de l’Économie Sociale et Solidaire a ...
Fragnière, Emmanuel, Nginamau, Maria Prisca Mbuilu, Place, Christophe   +2 more
core