Cyclization of the Analgesic α-Conotoxin Vc1.1 With a Non-Natural Linker: Effects on Structure, Stability, and Bioactivity. [PDF]
J Pept SciThis study cyclized conotoxin Vc1.1 using polyethylene glycol (PEG) linkers of different lengths and demonstrates that linker length modulates the peptide's helicity, thereby influencing its biological activity and stability. ABSTRACT α‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain.
Zhang Y +4 more
europepmc +2 more sources
Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugsα-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jinpeng Yu +8 more
doaj +2 more sources
α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. [PDF]
Br J Pharmacol, 2018 Cuny H +4 more
europepmc +2 more sources
Marine-Derived Ligands of Nicotinic Acetylcholine Receptors in Cancer Research [PDF]
Marine DrugsMarine sources contain compounds that act on a wide variety of systems, including ligand-gated ion channels. This review will focus on the effectors of nicotinic acetylcholine receptors (nAChRs), for which the diversity of ligands and modulators from ...
Igor E. Kasheverov +3 more
doaj +2 more sources
Conotoxins from sea snails as potential bone remodeling disruptors. [PDF]
JBMR PlusThe ocean provides food and shelter to diverse marine species, and it is an exceptional source of potential bioactive natural products with promising medicinal properties. Among these, α-conotoxins from venom sea snails show tremendous potential.
Iduarte-Frias B +6 more
europepmc +2 more sources
α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells. [PDF]
Mol Pharmacol, 2015 Hone AJ +8 more
europepmc +2 more sources
Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.
FASEB J, 2015 Heghinian MD +4 more
europepmc +2 more sources
Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms
Frontiers in Cellular Neuroscience, 2021 Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits.
Victor Tsetlin +11 more
doaj +1 more source
Correction to "α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells". [PDF]
Mol Pharmacol, 2016 europepmc +2 more sources
Marine Drugs, 2021 Cone snails are venomous marine predators that rely on fast-acting venom to subdue their prey and defend against aggressors. The conotoxins produced in the venom gland are small disulfide-rich peptides with high affinity and selectivity for their ...
Julien Giribaldi +7 more
doaj +1 more source