Results 81 to 90 of about 1,700,583 (126)

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

Marine Drugs
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ...
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak   +19 more
doaj   +1 more source

Corrigendum: Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA binding to α9α10 nicotinic receptors

Frontiers in Pharmacology, 2022
Marios Zouridakis, Athanasios Papakyriakou, Igor A. Ivanov, Igor E. Kasheverov, Igor E. Kasheverov, Victor Tsetlin, Victor Tsetlin, Socrates Tzartos, Socrates Tzartos, Petros Giastas   +9 more
doaj   +1 more source

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain

Marine Drugs
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan, Nan Wang, Xinyu Gao, Zihan Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +7 more
doaj   +1 more source

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype.

Journal of Medicinal Chemistry, 2018
Ri-lei Yu, Han-Shen Tae, Nargis Tabassum, Juan Shi, Tao Jiang, David John Adams   +5 more
semanticscholar   +1 more source

Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.

Angewandte Chemie, 2016
B. Carstens, G. Berecki, James T. Daniel, H. S. Lee, K. Jackson, Han-Shen Tae, Mahsa Sadeghi, J. Castro, T. O’Donnell, A. Deiteren, S. Brierley, D. Craik, David John Adams, R. Clark   +13 more
semanticscholar   +1 more source

Editorial: From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design

Frontiers in Pharmacology, 2020
Annette Nicke, Chris Ulens, Jean-Francois Rolland, Victor I. Tsetlin   +3 more
doaj   +1 more source

Modulation of Native and Recombinant GIRK1/2 Channels by Analgesic α-conotoxins

, 2020
Anuja R. Bony, J. McArthur, Rocio K. Finol-Urdaneta, David John Adams   +3 more
semanticscholar   +1 more source

A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. [PDF]

Commun Chem
Ge C, Tae HS, Lu L, Zhang Z, Huang Z, An B, Wang Y, Jiang T, Cai W, Chang S, Adams DJ, Yu R.   +11 more
europepmc   +1 more source

Engineering the ribbon isomer of α-conotoxins in the drug design application

, 2019
Xiaosa Wu
semanticscholar   +1 more source

Ancestral Sequence Reconstruction Provides Insights into the Structural Diversification and Neofunctionalization of T-superfamily Conotoxins in Conus. [PDF]

Mol Biol Evol
Espino SS, Koch TL, Gajewiak J, Giglio ML, Watkins M, Safavi-Hemami H, Olivera BM.   +6 more
europepmc   +1 more source