Results 1 to 10 of about 33,284 (165)

Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor [PDF]

Molecules, 2021
α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time ...
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
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Honokiol as an α-glucosidase inhibitor [PDF]

Frontiers in Pharmacology
Honokiol, a naturally occurring compound from Magnolia obovata Thunb., has many biological activities, but its anti-α-glucosidase activity is still unclear. Therefore, we determined its inhibitory effects against α-glucosidase.
Hua Zhu, Xin Zhong
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The formulation of lozenge using black mulberries (Morus nigra L.) leaf extract as an α-glucosidase inhibitor

Journal of Pharmacy and Bioallied Sciences, 2020
Background: Diabetes mellitus is a chronic metabolic disease, which possibly leads to kidney, brain, heart failure, and other organ complications, subsequently harming human health. These symptoms have been prevented using the leaf of black mulberry (BM),
Arif Budiman, Ferry F Sofian, Ni Made W S Santi, Diah L Aulifa   +3 more
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TLC-MS Bioautography-Based Identification of Free-Radical Scavenging, α‑Amylase, and α‑Glucosidase Inhibitor Compounds of Antidiabetic Tablet BGR-34 [PDF]

ACS Omega, 2020
Gaurav, Sultan Zahiruddin, Bushra Parveen, Mohammad Ibrahim, Ikshit Sharma, Sanchit Sharma, Anil Kumar Sharma, Rabea Parveen, Sayeed Ahmad   +8 more
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Characterization of α-Glucosidase Inhibitor Streptomyces sp. IPBCC.a.29.1556 Aqueous Extract: An Endophyte of Indonesian Ficus deltoidea

Indonesian Journal of Chemistry, 2022
Filamentous bacteria have been known as actinobacteria which could produce various secondary metabolites, including an α-glucosidase inhibitor. The α-glucosidase inhibitor has been identified to be potentially valuable for the treatment of diabetes ...
Isra Janatiningrum, Yulin Lestari, Dedy Duryadi Solihin, Anja Meryandini   +3 more
doaj   +1 more source

Identification of highly potent α-glucosidase inhibitors from Garcinia schomburgkiana and molecular docking studies [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
Twenty-two compounds (1-22) were isolated from the stems and twigs of Garcinia schomburgkiana. NMR, IR, UV, and MS were used for structural elucidation, and comparisons were made with previous reports. Compound 1 exhibited the most potent α-glucosidase
Thi My Lien Do, Nguyen-Minh-An Tran, Thuc-Huy Duong, Preecha Phuwapraisirisan, Nakorn Niamnont, Kewalin Inthanon, Jirapast Sichaem, Suttira Sedlak   +7 more
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Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors

Molecules, 2022
A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor.
Haibo Wang, Senling Tang, Guoqing Zhang, Yang Pan, Wei Jiao, Huawu Shao   +5 more
doaj   +1 more source

1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor [PDF]

, 2016
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Artola, Marta, Wu, Liang, Ferraz, Maria J., Kuo, Chi Lin, Raich, Lluís, Breen, Imogen Z., Offen, Wendy A., Codée, Jeroen D.C., Van Der Marel, Gijsbert A., Rovira, Carme, Aerts, Johannes M.F.G., Davies, Gideon J., Overkleeft, Herman S.   +12 more
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Antioxidant and antidiabetic compounds identification in several Indonesian underutilized Zingiberaceae spices using SPME-GC/MS-based volatilomics and in silico methods

Food Chemistry: X, 2022
This study aimed to identify compounds in 12 minor Zingiberaceae spices grown in Indonesia linked with in vitro α-glucosidase inhibitor and antioxidant (DPPH, FRAP, CUPRAC) activities using SPME-GC/MS volatilomics.
Fitra Tunnisa, Didah Nur Faridah, Ani Afriyanti, Dian Rosalina, Mohamad Ana Syabana, Noviyan Darmawan, Nancy Dewi Yuliana   +6 more
doaj   +1 more source

Inhibitory Mechanism of Quercimeritrin as a Novel α-Glucosidase Selective Inhibitor

Foods, 2023
In this study, 12 flavonoid glycosides were selected based on virtual screening and the literature, and Quercimeritrin was selected as the best selective inhibitor of α-glucosidase through in vitro enzyme activity inhibition experiments.
Fengyu Guo, Jie An, Minlong Wang, Weibo Zhang, Chong Chen, Xueying Mao, Siyuan Liu, Pengjie Wang, Fazheng Ren   +8 more
doaj   +1 more source