Results 111 to 120 of about 33,464 (260)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes. [PDF]

ACS Omega, 2023
Talab F, Ullah S, Alam A, Halim SA, Rehman NU, Zainab, Ali M, Latif A, Khan A, Al-Harrasi A, Ahmad M.   +10 more
europepmc   +1 more source

Antioxidant and α-glucosidase inhibitory activities of the leaf and stem of selected traditional medicinal plants [PDF]

, 2014
The study was aimed to determine the antioxidant and α-glucosidase inhibition activities of the stem and leaf of five different traditional medicinal plants. The studied plants exhibited varied antioxidant and α-glucosidase inhibition activities.
A. H., Nur Ashikin, Abas, Faridah, Abu Bakar Sajak, Azliana, Lee, Soo Yee, Mediani, Ahmed   +4 more
core  

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Phytochemical constituent, α-amylase and α-glucosidase inhibitory activities of Black Soybean (Glycine soja (L.) Merr.) ethanol extract

Pharmaciana
Diabetes is characterized as a hyperglycemic condition impacted by β-cell dysfunction and insulin deficiency. Black soybean (Glycine soja (L.) Merr.) is widely known as an origin of nutritious food that has shown activities in preventing cardiovascular ...
Afifah Bambang Sutjiatmo, Suci Narvikasari, Ananda Khairunisa Solihat, Wahyu Widowati, Hanna Sari Widya Kusuma, Fadhilah Haifa Zahiroh   +5 more
doaj   +1 more source

Combined Dipeptidyl Peptidase 4 Inhibitor and α-Glucosidase Inhibitor Treatment in Postprandial Hypoglycemia. [PDF]

Clin Diabetes, 2022
Broome DT, Kodali A, Phillips D, Makin V, Mendlovic D, Zimmerman RS.   +5 more
europepmc   +1 more source

Therapeutic potentials of black tea medicaments [PDF]

, 2014
Tea; a product of Camellia Sinensis plant is the most broadly used beverage in the world. Tea phytochemicals have been studied for the prevention of various chronic diseases, such as cancer, obesity, diabetes, jaundice, hypertension and inflammation ...
Mohapatra, S
core  

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Inhibition of α-glucosidase by melatonin derivatives: insights from kinetics, docking, and molecular dynamics simulations

Medicine in Drug Discovery
Type 2 diabetes mellitus (T2DM) represents a major global health challenge, emphasizing the need for effective strategies to manage postprandial hyperglycemia.
Ploenthip Puthongking, Bodee Nutho, Muhammad Subhan, Juthamat Ratha, Kiattawee Choowongkomon, Saranyu Khammuang, Kamonpan Sanachai   +6 more
doaj   +1 more source

Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity. [PDF]

Pharmaceutics, 2023
Aroua LM, Alosaimi AH, Alminderej FM, Messaoudi S, Mohammed HA, Almahmoud SA, Chigurupati S, Albadri AEAE, Mekni NH.   +8 more
europepmc   +1 more source