Results 91 to 100 of about 29,401 (218)

Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and α-MSH Realms

Biomolecules
Peptides continue to gain significance in the pharmaceutical arena. Since the unveiling of insulin in 1921, the Food and Drug Administration (FDA) has authorised around 100 peptides for various applications.
Othman Al Musaimi
doaj   +1 more source

Central Pathways Integrating Metabolism and Reproduction in Teleosts

Frontiers in Endocrinology, 2014
Energy balance plays an important role in the control of reproduction. However, the cellular and molecular mechanisms connecting the two systems are not well understood especially in teleosts.
Md eShahjahan, Takashi eKitahashi, Ishwar S Parhar   +2 more
doaj   +1 more source

Structural modification of the tripeptide KPV by reductive "glycoalkylation" of the lysine residue. [PDF]

PLoS ONE, 2018
Peptides that exhibit enzymatic or hormonal activities are regulatory factors and desirable therapeutic drugs because of their high target specificity and minimal side effects.
Abigael C Songok, Pradip Panta, William T Doerrler, Megan A Macnaughtan, Carol M Taylor   +4 more
doaj   +1 more source

α-Melanocyte-stimulating hormone prevents glutamate excitotoxicity in developing chicken retina via MC4R-mediated down-regulation of microRNA-194

Scientific Reports, 2015
Glutamate excitotoxicity is a common pathology to blinding ischemic retinopathies, such as diabetic retinopathy, glaucoma and central retinal vein or artery occlusion. The development of an effective interventional modality to glutamate excitotoxicity is
Yan Zhang, Qiyu Bo, Weihui Wu, Chang Xu, Guang-wei Yu, Shan Ma, Qian Yang, Yunshan Cao, Qian Han, Y. Ru, Xun Liu, Rui Hua Wei, Fei E Wang, Xiaomin Zhang, Xiaorong Li   +14 more
semanticscholar   +1 more source

Az ""alacsony T3 szindróma"" kialakulásáért felelős központi idegrendszeri szabályozó mechanizmusok tanulmányozása patkányban = Central regulatory mechanisms involved in the development of the 'low T3 syndrome' [PDF]

, 2008
A pályázat fő célja az éhezés és fertőzés hatására kialakuló centrális hipotiroidizmus kialakulásáért felelős központi idegrendszeri szabályozó mechanizmusok tanulmányozása volt.
Fekete, Csaba, Liposits, Zsolt, Wittmann, Gábor   +2 more
core  

Afamelanotide improves quality of life and light tolerance in Austrian erythropoietic protoporphyria patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Erythropoietic protoporphyria (EPP) is a rare genetic disorder characterized by severe phototoxic reactions that occur within minutes of light exposure. In clinical studies, afamelanotide has been shown to prolong pain‐free sun exposure, improve quality of life, and reduce the frequency and severity of phototoxic reactions ...
Magdalena Seidl‐Philipp, Hanna Schratter, Johanna Auer, Gerold Schwantzer, Maximilian Lammer, Philipp Hinteregger, Ines Vergeiner, Robert Gruber, Peter Wolf, Angelika Hofer   +9 more
wiley   +1 more source

Depigmenting Effect of Catechins

Molecules, 2009
The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA).
Masaru Toriyama, Kazuomi Sato
doaj   +1 more source

α-Melanocyte-stimulating Hormone Signaling Regulates Expression of microphthalmia, a Gene Deficient in Waardenburg Syndrome*

Journal of Biological Chemistry, 1998
The pituitary peptide α-melanocyte-stimulating hormone (α-MSH) stimulates melanocytes to up-regulate cAMP, but the downstream targets of cAMP are not well understood mechanistically.
E. Price, M. Horstmann, Audrey G. Wells, Kathy N. Weilbaecher, Clifford M. Takemoto, Mark W. Landis, David E. Fisher   +6 more
semanticscholar   +1 more source

A systematic immunohistochemical survey of the distribution patterns of GH, prolactin, somatolactin, β-TSH, β-FSH, β-LH, ACTH, and α-MSH in the adenohypophysis of Oreochromis niloticus , the Nile tilapia [PDF]

, 2018
Fish pituitary plays a central role in the control of growth, development, reproduction and adaptation to the environment. Several types of hormone-secreting adenohypophyseal cells have been characterised and localised in diverse teleost species.
Eppler, Elisabeth, Kasper, Romano, Reinecke, Manfred, Shved, Natallia, Takahashi, Akiyoshi   +4 more
core  

SemaGBA: A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley   +1 more source