Results 81 to 90 of about 29,401 (218)
Mechanism of Mitf inhibition and morphological differentiation effects of hirsein A on B16 melanoma cells revealed by DNA microarray [PDF]
, 2012 BackgroundWe have previously reported that hirsein A inhibits melanogenesis in B16 melanoma cells by downregulating the Mitf gene expression.ObjectiveIn this study, microarray was employed to determine the transcriptional response of B16 cells to hirsein
Han Junkyu +5 more
core +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng +3 more
wiley +1 more source
Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. [PDF]
, 2014 Narcolepsy is a chronic sleep disorder, likely with an autoimmune component. During 2009 and 2010, a link between A(H1N1)pdm09 Pandemrix vaccination and onset of narcolepsy was suggested in Scandinavia.
A. Cederlund +66 more
core +1 more source
Integrative Zoology, EarlyView.This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu +5 more
wiley +1 more source
Inhibition of Melanogenesis via Passive Immune Targeted Alpha-MSH Binder Polypeptide
CosmeticsAlpha-melanocyte stimulating hormone (α-MSH) is a hormone that stimulates the formation of melanin, which is responsible for protecting the skin from UV rays.
Se-Hyo Jeong +8 more
doaj +1 more source
Adipocyte, 2016 Communication between the brain and the adipose tissue has been the focus of many studies in recent years, with the “brain-fat axis” identified as a system that orchestrates the assimilation and usage of energy to maintain body mass and adequate fat ...
S. Shipp, M. Cline, E. Gilbert
semanticscholar +1 more source
Understanding pseudo-albinism in sole (Solea senegalensis): a transcriptomics and metagenomics approach [PDF]
, 2019 Pseudo-albinism is a pigmentation disorder observed in flatfish aquaculture with a complex, multi-factor aetiology. We tested the hypothesis that pigmentation abnormalities are an overt signal of more generalised modifications in tissue structure and ...
Carballo, Carlos +7 more
core +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Amyloid/Melanin distinctive mark in invertebrate immunity [PDF]
Invertebrate Survival Journal, 2012 Protostomes and Deuterostomes show the same nexus between melanin production, and amyloid fibril production, i.e., the presence of melanin is indissolubly linked to amyloid scaffold that, in turn, is conditioned by the redox status/cytoplasmic pH ...
A Grimaldi +7 more
doaj +2 more sources
Cell Proliferation, EarlyView.By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao +10 more
wiley +1 more source