Results 1 to 10 of about 91,213 (314)

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]

PLoS ONE, 2012
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Bötzel, Kai, Giese, Armin, Kamp, Frits, Kretzschmar, Hans, Levin, Johannes, Schmidt, Felix   +5 more
core   +24 more sources

The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein [PDF]

Autophagy Reports
Emerging evidence suggests that the propagation of α-synuclein pathology underlies the progression of Parkinson’s disease and supports the hypothesis that transmission of α-synuclein aggregates contributes to dopaminergic degeneration.
Emily Birnbaum, Zhenyu Yue
doaj   +2 more sources

Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. [PDF]

PLoS ONE, 2013
BACKGROUND:Cerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD).
Niklas Mattsson, Philip Insel, Duygu Tosun, Jing Zhang, Clifford R Jack, Douglas Galasko, Michael Weiner, Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +3 more sources

Recruitment of Aβ into α‑Synuclein Condensates Catalyzes Primary Nucleation of α‑Synuclein Aggregation [PDF]

ACS Central Science
Owen M. Morris, Alexander Röntgen, Zenon Toprakcioglu, Mariana Cali, Samuel Dada, Michele Vendruscolo   +5 more
doaj   +2 more sources

Cilazapril and benazepril mitigate neurodegeneration and α-synuclein accumulation in a cellular model of parkinson's disease. [PDF]

Sci Rep
Altunlu O, Hacimuftuoglu A, Okkay IF, Yesilyurt F, Yoruk MA, Ozkaraca M.   +5 more
europepmc   +3 more sources

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. [PDF]

PLoS ONE, 2011
Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, MPTP ...
Bobby Thomas, Allen S Mandir, Neva West, Ying Liu, Shaida A Andrabi, Wanda Stirling, Valina L Dawson, Ted M Dawson, Michael K Lee   +8 more
doaj   +1 more source

Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy

Cells, 2022
Aggregated alpha-synuclein (α-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson’s disease (IPD) and multiple system atrophy (MSA).
Berkiye Sonustun, Melek Firat Altay, Catherine Strand, Kirsten Ebanks, Geshanthi Hondhamuni, Thomas T. Warner, Hilal A. Lashuel, Rina Bandopadhyay   +7 more
doaj   +1 more source

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

Frontiers in Neuroscience, 2021
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell, Audrey T. Medeiros, John B. Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R. Morgan   +5 more
doaj   +1 more source

Central and peripheral α‐synuclein in Parkinson disease detected by seed amplification assay

Annals of Clinical and Translational Neurology, 2023
Objectives Detection of α‐synuclein aggregates by seed amplification is a promising Parkinson disease biomarker assay. Understanding intraindividual relationships of α‐synuclein measures could inform optimal biomarker development.
Lana M. Chahine, Thomas G. Beach, Charles H. Adler, Monica Hepker, Anumantha Kanthasamy, Scott Appel, Sandra Pritzkow, Michelle Pinho, Sherri Mosovsky, Geidy E. Serrano, Christopher Coffey, Michael C. Brumm, Luis M. A. Oliveira, Jamie Eberling, Brit Mollenhauer, For the Systemic Synuclein Sampling Study   +15 more
doaj   +1 more source

Gut mucosal cells transfer α-synuclein to the vagus nerve

JCI Insight, 2023
Epidemiological and histopathological findings have raised the possibility that misfolded α-synuclein protein might spread from the gut to the brain and increase the risk of Parkinson’s disease.
Rashmi Chandra, Arpine Sokratian, Katherine R. Chavez, Stephanie King, Sandip M. Swain, Joshua C. Snyder, Andrew B. West, Rodger A. Liddle   +7 more
doaj   +1 more source