Results 21 to 30 of about 91,213 (314)

Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway [PDF]

Frontiers in Aging Neuroscience, 2014
Abnormal accumulation of filamentous α-synuclein (α-syn) in neurons, regarded as Lewy bodies (LBs), are a hallmark of Parkinson disease (PD). Although the exact mechanism(s) underlying LBs formation remains unknown, autophagy and ER stress response have emerged as two important pathways affecting α-syn aggregation.
Jiang, Peizhou, Gan, Ming, Lin, Wen-Lang, Yen, Shu-Hui C.   +3 more
openaire   +3 more sources

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

Frontiers in Neuroscience, 2018
Synucleinopathies represent a group of neurodegenerative disorders which are characterized by intracellular accumulation of aggregated α-synuclein. α-synuclein misfolding and oligomer formation is considered a major pathogenic trigger in these disorders.
Martin Kallab, Marcos Herrera-Vaquero, Malin Johannesson, Fredrik Eriksson, Jessica Sigvardson, Werner Poewe, Gregor K. Wenning, Eva Nordström, Nadia Stefanova   +8 more
doaj   +1 more source

Chicago sky blue 6B inhibits α-synuclein aggregation and propagation

Molecular Brain, 2022
Abnormal deposition of α-synuclein aggregates in Lewy bodies and Lewy neurites is the hallmark lesion in Parkinson’s disease (PD). These aggregates, thought to be the culprit of disease pathogenesis, spread throughout the brain as the disease progresses.
Joo-Ok Min, Timo Strohäker, Byung-Chul Jeong, Markus Zweckstetter, Seung-Jae Lee   +4 more
doaj   +1 more source

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]

, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Fillon, Gwenaëlle, Gai, Wei-Ping, Gysbers, Amanda, Haass, Christian, Halliday, Glenda,, Hansen, Hanne, Jensen, Poul, Kahle, Philipp, Kragh, Christine, Lubetzki, Catherine, Neumann, Manuela, Richter-Landsberg, Christian, Smith, Wanli, Zalc, Bernard   +13 more
core   +3 more sources

Extracellular α-synuclein levels are regulated by neuronal activity

Molecular Neurodegeneration, 2018
Background α-Synuclein is a presynaptic protein abundant in the cytoplasmic compartment of neurons, whereas its presence in the extracellular space has also been observed under physiological conditions.
Kaoru Yamada, Takeshi Iwatsubo
doaj   +1 more source

Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity [PDF]

Frontiers in Aging Neuroscience, 2014
The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies.
Mustafa eArdah, Katerina ePaleologou, Guohua eLv, Salema eAbul Khair, Abdullah eAl Kendi, Saeed eMinhas, Taleb eAl-Tel, Abdulmonem eAl-Hayani, Mohammed eHaque, David eEliezer, Omar eEl-Agnaf, Omar eEl-Agnaf   +11 more
openaire   +3 more sources

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Acta Neuropathologica Communications, 2021
Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD.
Charlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, Laura A. Volpicelli-Daley   +8 more
doaj   +1 more source

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers [PDF]

Frontiers in Aging Neuroscience, 2014
Mutations in the leucine-rich repeat kinase 2 gene are the most common cause of autosomal dominant Parkinson's disease (PD). To assess the cerebrospinal fluid (CSF) levels of α-synuclein oligomers in symptomatic and asymptomatic leucine-rich repeat kinase 2 mutation carriers, we used enzyme-linked immunosorbent assays (ELISA) to investigate total and ...
Aasly, Jan, Johansen, Krisztina, Brønstad, Gunnar, Warø, Bjørg Johanne, Majbour, NK, Varghese, S, Alzahmi, F, Paleologou, KE, Amer, DAM, Al-Hayani, A, El-Agnaf, OMA   +10 more
openaire   +4 more sources

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein [PDF]

Frontiers in Behavioral Neuroscience, 2015
Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems.
Bentea, Eduard, Van der Perren, Anke, Van Liefferinge, Joeri, El Arfani, Anissa, Albertini, Giulia, Demuyser, Thomas, Merckx, Ellen, Michotte, Yvette, Smolders, Ilse, Baekelandt, Veerle, Massie, Ann   +10 more
openaire   +4 more sources

Midbrain catecholaminergic neurons co-express α-synuclein and tau in progressive supranuclear palsy [PDF]

Frontiers in Neuroanatomy, 2015
To analyze the frequency and distribution of α-synuclein deposits in progressive supranuclear palsy (PSP).The brains of 25 cases of pathologically confirmed PSP were evaluated with immunohistochemistry for α-synuclein and tau. Multiple immunofluorescent stains were applied to analyze the expression of tau and α-synuclein aggregates in catecholaminergic
María Elena eErro Aguirre, María Victoria eZelaya, Javier eSánchez Ruiz de Gordoa, María Teresa eTuñón, José Luis eLanciego, José Luis eLanciego   +5 more
openaire   +4 more sources