Results 41 to 50 of about 91,213 (314)

Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System [PDF]

, 2015
Background:Alpha-synuclein containing inclusions in neurons, the characteristic pathological lesions of Parkinson’s disease (PD), are not limited to the central nervous system, but also affect the enteric nervous system (ENS).
A.G. Corbillé, C. Preterre, F. Letournel, G. Balloy, M. Neunlist, P. Derkinderen   +5 more
core   +3 more sources

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

eLife, 2020
Abnormal α-synuclein aggregation has been implicated in several diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether ...
Genjiro Suzuki, Sei Imura, Masato Hosokawa, Ryu Katsumata, Takashi Nonaka, Shin-Ichi Hisanaga, Yasushi Saeki, Masato Hasegawa   +7 more
doaj   +1 more source

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]

, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D, Ihse, Elisabet, Lawrence, Roger, Masliah, Eliezer, van Wijk, Xander M, Yamakado, Hodaka   +5 more
core   +2 more sources

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.

, 2019
Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood.
Anichtchik, O., Ashery, U., Bar-On, D., Calo’, L., Dalley, J., Giese, A., Griesinger, C., Iovino, M., Leonov, A., Ryazanov, S., Spillantini, M., Wegrzynowicz, M., Xia, J.   +12 more
core   +1 more source

Clearing extracellular alpha-synuclein from cerebrospinal fluid: A new therapeutic strategy in parkinson’s disease [PDF]

, 2018
This concept article aims to show the rationale of targeting extracellular α-Synuclein (α-Syn) from cerebrospinal fluid (CSF) as a new strategy to remove this protein from the brain in Parkinson’s disease (PD). Misfolding and intracellular aggregation of
Fernández García, Benjamín, Menéndez González, Manuel, Padilla Zambrano, H. S., Tomás Zapico, Cristina   +3 more
core   +3 more sources

MOESM5 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 5. Negative binomial mixed-effects model analysis of pser129 quantifications.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Clinical Neuropathology image 5-2014: α-synuclein pathology in the ependyma in Parkinson’s disease [PDF]

Clinical Neuropathology, 2014
Not available.
openaire   +2 more sources

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

Neurobiology of Disease, 2013
Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease patients where it mainly accumulates in the Lewy bodies. Several groups have studied the role of phosphorylation at the S129 in α-synuclein in a rat model for ...
Fabia Febbraro, Gurdal Sahin, Aina Farran, Sofia Soares, Poul H. Jensen, Deniz Kirik, Marina Romero-Ramos   +6 more
doaj   +1 more source

Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss

Scientific Reports, 2021
Synucleinopathies are neurodegenerative diseases in which α-synuclein protein accumulates in neurons and glia. In these diseases, α-synuclein forms dense intracellular aggregates that are disease hallmarks and actively contribute to tissue pathology ...
Andrew D. Sauerbeck, Evan Z. Goldstein, Anthony N. Alfredo, Michael Norenberg, Alexander Marcillo, Dana M. McTigue   +5 more
doaj   +1 more source

MOESM2 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 2. List of antibodies, references and working concentrations.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source