Results 51 to 60 of about 91,213 (314)

Modelling α-synuclein processing in primary patient cells for pharmacological intervention

Exploration of Medicine, 2023
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the ...
Jessica K. Smith, George D. Mellick, Alex M. Sykes   +2 more
doaj   +1 more source

Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]

, 2019
Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola, Conde, Melisa Ailén, Iglesias González, Pablo Andrés, Salvador, Gabriela Alejandra, Uranga, Romina Maria   +4 more
core   +1 more source

MOESM4 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 4. List of the abbreviations of brain regions used in the figures.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

Redox Biology, 2018
The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play important roles in α-synuclein-induced microglial activation.
Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang   +9 more
openaire   +3 more sources

Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

Molecules, 2023
α-Synuclein aggregation under pathological conditions is one of the causes of related neurodegenerative diseases. PROTACs (proteolysis targeting chimeras) are bifunctional small molecules that induce a post-translational erasure of proteins via the ...
Tianzhi Wen, Jian Chen, Wenqian Zhang, Jiyan Pang   +3 more
doaj   +1 more source

Cyclin-G-associated kinase modifies alpha-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study [PDF]

, 2011
Although family history is a well-established risk factor for Parkinson's disease (PD), fewer than 5% of PD cases can be attributed to known genetic mutations.
Dumitriu, Alexandra, Goldwurm, Stefano, Latourelle, Jeanne C., Lindquist, Susan, Myers, Richard H., Pacheco, Chris D., Pezzoli, Gianni, Rochet, Jean-Christophe, Strathearn, Katherine E., Wilk, Jemma B.   +9 more
core   +2 more sources

MOESM3 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 3. Examples of pser129-positive inclusions at high and low magnifications.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Heliyon, 2018
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death.
Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo   +6 more
doaj   +1 more source

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease

Redox Biology, 2021
The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro.
De-Hai Gou, Ting-Ting Huang, Wen Li, Xin-Di Gao, Caroline Haikal, Xin-He Wang, Dong-Yan Song, Xin Liang, Lin Zhu, Yong Tang, Chen Ding, Jia-Yi Li   +11 more
doaj   +1 more source

MOESM6 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 6. Microglial morphology analysis reveals no differences in microglial activation between groups.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source