Results 81 to 90 of about 91,213 (314)
β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein
Nature CommunicationsParkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms droplets via liquid-liquid phase separation (LLPS), followed by liquid-solid phase
Xi Li +18 more
doaj +1 more source
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
PLoS Genetics, 2021 Parkinson's disease is a neurodegenerative disorder associated with misfolding and aggregation of α-synuclein as a hallmark protein. Two yeast strain collections comprising conditional alleles of essential genes were screened for the ability of each ...
Blagovesta Popova +11 more
doaj +1 more source
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2 [PDF]
, 2017 Mutations in the genes encoding LRRK2 and α-synuclein cause autosomal dominant forms of familial Parkinson's disease (PD). Fibrillar forms of α-synuclein are a major component of Lewy bodies, the intracytoplasmic proteinaceous inclusions that are a ...
Biskup, Saskia +10 more
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Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease. [PDF]
, 2017 Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra.
Anandhan, Annadurai +10 more
core +2 more sources
Advanced Functional Materials, EarlyView.A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang +9 more
wiley +1 more source
npj Parkinson's Disease, 2022 The pathological hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) with aggregated α-synuclein being the major component. The abnormal α-synuclein aggregates transfer between cells, recruit endogenous α-synuclein into toxic LBs ...
Mingmin Yan +7 more
doaj +1 more source
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase [PDF]
, 2016 Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded α-synuclein is limited.
Abramov, A +5 more
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Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Differential expression of alpha-synuclein in hippocampal neurons.
PLoS ONE, 2014 α-Synuclein is the major pathological component of synucleinopathies including Parkinson's disease and dementia with Lewy bodies. Recent studies have demonstrated that α-synuclein also plays important roles in the release of synaptic vesicles and ...
Katsutoshi Taguchi +7 more
doaj +1 more source
Ambroxol effects in glucocerebrosidase and -synuclein transgenic mice [PDF]
, 2016 Objective. Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase.
Bezard, E +3 more
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