Results 111 to 120 of about 902,322 (261)

Evaluation of α-tubulin, detyrosinated α-tubulin, and vimentin in CTCs: identification of the interaction between CTCs and blood cells through cytoskeletal elements

Breast Cancer Research, 2018
Background Circulating tumor cells (CTCs) are the major players in the metastatic process. A potential mechanism of cell migration and invasion is the formation of microtentacles in tumor cells.
G. Kallergi, D. Aggouraki, N. Zacharopoulou, C. Stournaras, V. Georgoulias, S. S. Martin   +5 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Isolation of α-tubulin genes from the human malaria parasite, Plasmodium falciparum: Sequence analysis of α-tubulin

, 1989
As a step towards identifying exploitable differences between host and parasite at the molecular level, we have isolated and sequenced genomic clones encompassing and entire α-tubulin gene (designated α-tubulin I) from the human malaria parasite ...
Sims, P. F G, Scaife, J. G., Holloway, S. P., Delves, C. J., Hyde, J. E.   +4 more
core   +1 more source

Disrupting VDAC1–tubulin interaction uncovers crosstalk between mitochondrial and microtubule functions with implication to cancer therapy

Cellular and Molecular Life Sciences
Tubulin, a key component of the microtubule (MT) cytoskeleton, interacts with the mitochondrial gatekeeper protein VDAC1. Using a peptide array, we identified four VDAC1-binding sites in α-tubulin-1B.
Manikandan Santhanam, Anna Shteinfer-Kuzmine, Omer Bushusha, Ran Zalk, Larisa Gheber, Varda Shoshan-Barmatz   +5 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Spot No. 2514 is a fragment of α-tubulin

, 2013
A) Spot 2514 migrates with a molecular mass below 40 kDa. The identified peptides from the spot are distributed in the N-terminal of α-tubulin and spot 2514 thus corresponds to a fragment of α-tubulin, since α-tubulin possesses a molecular mass around 50
Bent Honoré (484780), Louise Thorlacius-Ussing (484777), Henrik Vorum (414798), Maja Ludvigsen (484778), Svend Kirkeby (484779)   +4 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs [PDF]

, 2000
The surface topography of opened-up microtubule walls (sheets) decorated with monomeric and dimeric kinesin motor domains was investigated by freeze-drying and unidirectional metal shadowing.
Mandelkow, Eckhard, Song, Young Hwa, Woehlke, Guenther, Tittmann, Peter, Hoenger, Andreas, Gross, Heinz, Doerhoefer, Monika   +6 more
core   +1 more source

Скринінг нітроанілінів на спорідненість до α-тубуліну міскантусу для їх використання у поліплоїдизації рослин цього роду

Фактори експериментальної еволюції організмів, 2016
Aim. Biofuel is one of the most prominent directions in contemporary energy technologies. In many cases polyploids are superior to their original forms.
О. В. Мельничук, С. П. Ожерєдов, Д. Б. Рахметов, А. І. Ємець, Я. Б. Блюм   +4 more
doaj  

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source