Results 1 to 10 of about 206 (102)

Matrix stiffness‐induced α‐tubulin acetylation is required for skin fibrosis formation through activation of Yes‐associated protein

MedComm, 2023
Skin fibrosis, a pathological process featured by fibroblast activation and extracellular matrix (ECM) deposition, makes a significant contribution to morbidity.
Dongsheng Wen, Chiakang Ho, Qingfeng Li   +2 more
exaly   +2 more sources

Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation

Biology, 2023
Microtubules (MTs), dynamic polymers of α/β-tubulin heterodimers found in all eukaryotes, are involved in cytoplasm spatial organization, intracellular transport, cell polarity, migration and division, and in cilia biology.
Bruno Carmona, H Susana Marinho, Sofia Nolasco   +2 more
exaly   +3 more sources

A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation

Redox Biology, 2021
The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD+-dependent deacetylase SIRT2 to regulate acetyl α-tubulin (K40) levels on microtubules. NQO1 catalyzes the oxidation of NADH to NAD+
David Siegel, Stephanie Bersie, Peter S Harris   +2 more
exaly   +3 more sources

Expression of α-Tubulin Acetyltransferase 1 and Tubulin Acetylation as Selective Forces in Cell Competition

Cells, 2021
The wound healing response of fibroblasts critically depends on the primary cilium, a sensory organelle protruding into the environment and comprising a stable axonemal structure.
Irem Kılıҫ, Constanza Tapia Contreras, Sigrid Hoyer-Fender   +2 more
exaly   +3 more sources

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources

Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA [PDF]

Proceedings of the National Academy of Sciences, 2012
Acetylation of lysine residues is an important posttranslational modification found in all domains of life. α-tubulin is specifically acetylated on lysine 40, a modification that serves to stabilize microtubules of axons and cilia. Whereas histone acetyltransferases have been extensively studied, there is no structural and mechanistic information ...
Taschner, M., Vetter, M., and Lorentzen, E.   +5 more
openaire   +4 more sources

Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients

Platelets, 2023
Platelet inhibition is the main treatment strategy to prevent atherothrombotic complications after acute coronary syndrome or percutaneous coronary intervention.
Valentine Robaux, Shakeel Kautbally, Audrey Ginion, Mélanie Dechamps, Sibille Lejeune, Nassiba Menghoum, Luc Bertrand, Anne-Catherine Pouleur, Sandrine Horman, Christophe Beauloye   +9 more
doaj   +1 more source

Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary.

PLoS ONE, 2022
Microtubule acetylation is found in populations of stable, long-lived microtubules, occurring on the conserved lysine 40 (K40) residue of α-tubulin by α-tubulin acetyltransferases (αTATs).
Matthew Antel, Taylor Simao, Muhammed Burak Bener, Mayu Inaba   +3 more
doaj   +1 more source

α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila.

PLoS ONE, 2023
Posttranslational modification of tubulin increases the dynamic complexity and functional diversity of microtubules. Acetylation of α-tubulin at Lys-40 is a highly conserved posttranslational modification that has been shown to improve the flexibility ...
Xiaoxiao Niu, Chuan-Xi Mao, Shan Wang, Xiongxiong Wang, Youyu Zhang, Juncheng Hu, Ran Bi, Zhihua Liu, Jin Shan   +8 more
doaj   +1 more source

The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells

Cancer Cell International, 2020
Background Reversible acetylation of α-tubulin has been implicated in modulating microtuble structures and functions, which may subsequently involve in cellular apoptosis and autophage.
Qilin Wang, Xiangguo Liu
doaj   +1 more source