Matrix stiffness-induced α-tubulin acetylation is required for skin fibrosis formation through activation of Yes-associated protein [PDF]
MedComm, 2023 Skin fibrosis, a pathological process featured by fibroblast activation and extracellular matrix (ECM) deposition, makes a significant contribution to morbidity.
Ya Gao, Yifan Zhang, Chia-Kang Ho
exaly +4 more sources
Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation [PDF]
Communications Biology, 2023 In response to nutritional stress, microtubules in cells of the Drosophila female germline are depleted from the cytoplasm and accumulate cortically. This triggers aggregation of mRNPs into large processing bodies (P-bodies) and oogenesis arrest.
Frank Wippich +3 more
doaj +3 more sources
MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A [PDF]
iScienceSummary: Mitofusin-2 (MFN2), a large GTPase residing in the mitochondrial outer membrane and mutated in Charcot-Marie-Tooth type 2 disease (CMT2A), is a regulator of mitochondrial fusion and tethering with the ER.
Atul Kumar +10 more
doaj +5 more sources
A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation [PDF]
Redox Biology, 2021 The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD+-dependent deacetylase SIRT2 to regulate acetyl α-tubulin (K40) levels on microtubules. NQO1 catalyzes the oxidation of NADH to NAD+
David Siegel +2 more
exaly +4 more sources
Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation [PDF]
Frontiers in Pharmacology, 2019 Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the underlying mechanism is unclear.
Chen-Guang Li +8 more
doaj +4 more sources
α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila. [PDF]
PLoS ONE, 2023 Posttranslational modification of tubulin increases the dynamic complexity and functional diversity of microtubules. Acetylation of α-tubulin at Lys-40 is a highly conserved posttranslational modification that has been shown to improve the flexibility ...
Xiaoxiao Niu +8 more
doaj +2 more sources
The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells [PDF]
Cancer Cell International, 2020 Background Reversible acetylation of α-tubulin has been implicated in modulating microtuble structures and functions, which may subsequently involve in cellular apoptosis and autophage.
Qilin Wang, Xiangguo Liu
doaj +2 more sources
Vimentin inhibits α-tubulin acetylation via enhancing α-TAT1 degradation to suppress the replication of human parainfluenza virus type 3. [PDF]
PLoS Pathogens, 2022 We previously found that, among human parainfluenza virus type 3 (HPIV3) proteins, the interaction of nucleoprotein (N) and phosphoprotein (P) provides the minimal requirement for the formation of cytoplasmic inclusion bodies (IBs), which are sites of ...
Pengfei Liu +5 more
doaj +2 more sources
NAT10 promotes proliferation, invasion, and epithelial–mesenchymal transition in hepatocellular carcinoma through α-tubulin acetylation [PDF]
Cell Adhesion & MigrationHepatocellular carcinoma (HCC) remains a global health challenge due to its high metastatic potential and poor prognosis. This study investigated the role and underlying molecular mechanisms of N-acetyltransferase 10 (NAT10)-mediated α-tubulin ...
Haogang Yu +10 more
doaj +2 more sources
Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation
Biology, 2023 Microtubules (MTs), dynamic polymers of α/β-tubulin heterodimers found in all eukaryotes, are involved in cytoplasm spatial organization, intracellular transport, cell polarity, migration and division, and in cilia biology.
Helena Soares +2 more
exaly +3 more sources