Results 21 to 30 of about 1,007,835 (176)

Paclitaxel induces NM2-dependent cellular contraction through GEF-H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells. [PDF]

Mol Oncol
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Asensio-Juárez G, Pérez-Díaz R, Ramos-Solano H, Garrido-Casado M, Talayero VC, Vicente-Manzanares M.   +5 more
europepmc   +2 more sources

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice.

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources

Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA [PDF]

Proceedings of the National Academy of Sciences, 2012
Acetylation of lysine residues is an important posttranslational modification found in all domains of life. α-tubulin is specifically acetylated on lysine 40, a modification that serves to stabilize microtubules of axons and cilia. Whereas histone acetyltransferases have been extensively studied, there is no structural and mechanistic information ...
Taschner, M., Vetter, M., and Lorentzen, E.   +5 more
openaire   +4 more sources

Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary.

PLoS ONE, 2022
Microtubule acetylation is found in populations of stable, long-lived microtubules, occurring on the conserved lysine 40 (K40) residue of α-tubulin by α-tubulin acetyltransferases (αTATs).
Matthew Antel, Taylor Simao, Muhammed Burak Bener, Mayu Inaba   +3 more
doaj   +1 more source

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization [PDF]

, 2023
Emerging evidence supports that altered α-tubulin acetylation occurs in Parkinson’s disease (PD), a neurodegenerative disorder characterized by the deposition of α-synuclein fibrillary aggregates within Lewy bodies and nigrostriatal neuron degeneration ...
Rolando C., Basellini M. J., Cappelletti G., Calogero A. M., Longhena F., Pezzoli G., Mazzetti S., Isilgan H. B., Bellucci A.   +8 more
core   +3 more sources

Alpha-Tubulin Acetylation in Trypanosoma cruzi: A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosomatids have a cytoskeleton arrangement that is simpler than what is found in most eukaryotic cells. However, it is precisely organized and constituted by stable microtubules.
Victoria Lucia Alonso, Victoria Lucia Alonso, Mara Emilia Carloni, Camila Silva Gonçalves, Camila Silva Gonçalves, Gonzalo Martinez Peralta, Gonzalo Martinez Peralta, Maria Eugenia Chesta, Alejandro Pezza, Luis Emilio Tavernelli, Maria Cristina M. Motta, Maria Cristina M. Motta, Esteban Serra, Esteban Serra   +13 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F-actin distribution. [PDF]

FEBS Open Bio
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Joseph TV, Pham AB, Bornes KE, Hammad RH, Rousseve-Ross CA, Huckaba TM, Watt TJ, Toro TB.   +7 more
europepmc   +2 more sources

Microtubule acetylation dyshomeostasis in Parkinson’s disease

Translational Neurodegeneration, 2023
The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system.
Padmashri Naren, Khan Sabiya Samim, Kamatham Pushpa Tryphena, Lalitkumar K. Vora, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri   +6 more
doaj   +1 more source

Dose-dependent induction by FQI1 of extra α-tubulin- and γ-tubulin-positive structures.

, 2022
(A) Top: Schematic of treatments of synchronized RPE cells in quiescence by serum starvation. Bottom: Representative images of cells stained for γ-tubulin, α-tubulin and DNA from a total of at least 60 cells over three independent biological experiments ...
Jagesh V. Shah (116400), Sarah A. Yunes (12878359), Scott E. Schaus (1319193), Julian H. Kwan (12878362), Emily A. York (12878371), Andrew Emili (65325), Niranjana Pokharel (12878368), Ulla Hansen (3523916), Jessica M. Biagi (12878365), Kelly George (8977034), Hang Gyeong Chin (9570), Kuan-Chung Su (9232640), Jennifer L. S. Willoughby (8977031)   +12 more
core   +1 more source

Antibody-free targeted proteomics assay for absolute measurement of α-tubulin acetylation

, 2020
Acetylation of α-tubulin at conserved lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellular activities.
Wali, Gautam, Shah, Alok K., Sue, Carolyn M., Hill, Michelle M., Mackay-Sim, Alan, Shah, Alok K, Hill, Michelle M, Sue, Carolyn M   +7 more
core   +1 more source