Results 21 to 30 of about 17,027 (139)

HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy

Cells, 2022
Histone deacetylase (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as α-tubulin. HDAC6 dysfunction is associated with several pathological conditions in renal disorders, including UUO-induced fibrotic kidneys and ...
Lang Shi, Zhixia Song, Chenglong Li, Fangjing Deng, Yao Xia, Jing Huang, Xiongfei Wu, Jiefu Zhu   +7 more
doaj   +1 more source

Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages

Frontiers in Immunology, 2019
Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome.
Qiong-zhen Zeng, Fan Yang, Chen-guang Li, Li-hui Xu, Xian-hui He, Feng-yi Mai, Chen-ying Zeng, Cheng-cheng Zhang, Qing-bing Zha, Dong-yun Ouyang   +9 more
doaj   +1 more source

Tubulin acetylation alone does not affect kinesin-1 velocity and run length in vitro. [PDF]

PLoS ONE, 2012
Kinesin-1 plays a major role in anterograde transport of intracellular cargo along microtubules. Currently, there is an ongoing debate of whether α-tubulin K40 acetylation directly enhances the velocity of kinesin-1 and its affinity to the microtubule ...
Wilhelm J Walter, Václav Beránek, Elisabeth Fischermeier, Stefan Diez   +3 more
doaj   +1 more source

Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules. [PDF]

PLoS ONE, 2012
The αβ-tubulin subunits of microtubules can undergo a variety of evolutionarily-conserved post-translational modifications (PTMs) that provide functional specialization to subsets of cellular microtubules. Acetylation of α-tubulin residue Lysine-40 (K40)
Virupakshi Soppina, Jeffrey F Herbstman, Georgios Skiniotis, Kristen J Verhey   +3 more
doaj   +1 more source

Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin

Cell Death Discovery, 2021
Acetylation of α-tubulin lysine 40 (αK40) contributes to microtubule (MT) stability and is essential for neuronal development and function, whereas excessive αK40 deacetylation is observed in neurodegenerative disorders including Alzheimer’s disease (AD).
Taegwan Yun, Hyo Rim Ko, Dong-Kyu Jo, Kye Won Park, Sung-Woo Cho, Jihoe Kim, Jee-Yin Ahn   +6 more
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Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization

Cell Death Discovery, 2021
The posttranslational modifications (PTMs) of microtubules have been reported to play an important role in cancer aggressiveness, including apoptosis resistance.
Onsurang Wattanathamsan, Rawikorn Thararattanobon, Ratchanee Rodsiri, Pithi Chanvorachote, Chanida Vinayanuwattikun, Varisa Pongrakhananon   +5 more
doaj   +1 more source

Microtubule Acetylation Is Required for Mechanosensation in Drosophila

Cell Reports, 2018
Summary: At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown ...
Connie Yan, Fei Wang, Yun Peng, Claire R. Williams, Brian Jenkins, Jill Wildonger, Hyeon-Jin Kim, Jonathan B. Perr, Joshua C. Vaughan, Megan E. Kern, Michael R. Falvo, E. Timothy O’Brien, III, Richard Superfine, John C. Tuthill, Yang Xiang, Stephen L. Rogers, Jay Z. Parrish   +16 more
doaj   +1 more source

Ethanol Administration in Mice Leads to Sex-Specific Changes in the Acetylation of α-Tubulin in the Cerebellum

Brain Sciences
Background: Acetylation of α-tubulin is an important post-translational modification that helps maintain microtubules’ stability and dynamics, including axonal transport, cell signaling, and overall neuronal integrity.
Abosede Elesinnla, Rehana Khatoon, Nicholas Kleinert, Junfang Wu, Jaylyn Waddell, Tibor Kristian   +5 more
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Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. [PDF]

PLoS Genetics, 2016
Familial Dysautonomia (FD) is a neurodegenerative disease in which aberrant tissue-specific splicing of IKBKAP exon 20 leads to reduction of IKAP protein levels in neuronal tissues. Here we generated a conditional knockout (CKO) mouse in which exon 20 of
Shiran Naftelberg, Ziv Abramovitch, Shani Gluska, Sivan Yannai, Yuvraj Joshi, Maya Donyo, Keren Ben-Yaakov, Tal Gradus, Jonathan Zonszain, Chen Farhy, Ruth Ashery-Padan, Eran Perlson, Gil Ast   +12 more
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Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro

Frontiers in Pharmacology, 2022
Ovarian cancer is the second leading cause of death of female gynecological malignant tumor patients worldwide. Although surgery and chemotherapy have achieved dramatic achievement, the mortality remains high, resulting in the demand for new specific ...
Lulu Si, Lulu Si, Tianjiao Lai, Tianjiao Lai, Junru Zhao, Yuxi Jin, Yuxi Jin, Meng Qi, Meng Qi, Mingyue Li, Mingyue Li, Hanlin Fu, Hanlin Fu, Xiaojing Shi, Liying Ma, Liying Ma, Liying Ma, Ruixia Guo, Ruixia Guo   +18 more
doaj   +1 more source