Results 41 to 50 of about 1,007,835 (176)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

VIM negatively regulates the acetylation of α-tubulin, inhibiting the formation of HPIV3 IBs.

, 2022
(A) VIM downregulated α-tubulin acetylation. N-Myc, HA–P, and Flag–VIM plasmids were transfected alone or together, and the acetylation of α-tubulin was detected as well as the overexpressed proteins.
Jingyi Ma (3720553), Mingzhou Chen (741699), Pengfei Liu (136115), Yali Qin (749233), Dongning Jin (10953856), Shengwei Zhang (321384)   +5 more
core   +1 more source

Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. [PDF]

PLoS Genetics, 2016
Familial Dysautonomia (FD) is a neurodegenerative disease in which aberrant tissue-specific splicing of IKBKAP exon 20 leads to reduction of IKAP protein levels in neuronal tissues. Here we generated a conditional knockout (CKO) mouse in which exon 20 of
Shiran Naftelberg, Ziv Abramovitch, Shani Gluska, Sivan Yannai, Yuvraj Joshi, Maya Donyo, Keren Ben-Yaakov, Tal Gradus, Jonathan Zonszain, Chen Farhy, Ruth Ashery-Padan, Eran Perlson, Gil Ast   +12 more
doaj   +1 more source

Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro

Frontiers in Pharmacology, 2022
Ovarian cancer is the second leading cause of death of female gynecological malignant tumor patients worldwide. Although surgery and chemotherapy have achieved dramatic achievement, the mortality remains high, resulting in the demand for new specific ...
Lulu Si, Lulu Si, Tianjiao Lai, Tianjiao Lai, Junru Zhao, Yuxi Jin, Yuxi Jin, Meng Qi, Meng Qi, Mingyue Li, Mingyue Li, Hanlin Fu, Hanlin Fu, Xiaojing Shi, Liying Ma, Liying Ma, Liying Ma, Ruixia Guo, Ruixia Guo   +18 more
doaj   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration

Journal of Biomedical Science, 2021
Background The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell–cell adhesion, cell proliferation and cell cycle. However, the mechanisms of
Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De La Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom, Catherine E. Costello   +7 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Acetylation of α-tubulin.

, 2013
Western blots for tubulin (pan-Tub) and acetyl-α-tubulin (Ac-Tub) in brain extracts of WT and KO mice, both female and male (A, B). Genotypes are indicated at the top of each lane and sex at the bottom.
Zhenxia Qin (311680), Mitri K. Khoury (479922), Rana N. Khoury (479921), Rachel S. Kaufman (479920), Dana W. Aswad (311681)   +4 more
core   +1 more source

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression [PDF]

, 2018
The role of formins in microtubules is not well understood. In this study, we have investigated the mechanism by which INF2, a formin mutated in degenerative renal and neurological hereditary disorders, controls microtubule acetylation.
Laura Rangel, Miguel A. Alonso, Miguel Bernabé-Rubio, Casares-Arias, Javier, Isabel Correas, Rangel, Laura, Bernabé-Rubio, Miguel, Laura Fernández-Martín, Fernández-Martín, Laura, Fernández-Barrera, Jaime, Correas, Isabel, Alonso, Miguel A., Jaime Fernández-Barrera, Javier Casares-Arias   +13 more
core   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source