Results 1 to 10 of about 20,469 (144)

Microtubule Acetylation Is Required for Mechanosensation in Drosophila [PDF]

Cell Reports, 2018
Summary: At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown ...
Yun Peng, Jill Wildonger, Joshua C Vaughan   +2 more
exaly   +4 more sources

Microtubule acetylation dyshomeostasis in Parkinson’s disease [PDF]

Translational Neurodegeneration, 2023
The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system.
Padmashri Naren, Khan Sabiya Samim, Kamatham Pushpa Tryphena, Lalitkumar K. Vora, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri   +6 more
doaj   +2 more sources

p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation [PDF]

Cell Death and Disease, 2021
The cyclin-dependent kinase inhibitor p27Kip1 (p27) has been involved in promoting autophagy and survival in conditions of metabolic stress. While the signaling cascade upstream of p27 leading to its cytoplasmic localization and autophagy induction has ...
Ada Nowosad, Justine Creff, Pauline Jeannot, Raphael Culerrier, Patrice Codogno, Stephane Manenti, Laurent Nguyen, Arnaud Besson   +7 more
doaj   +2 more sources

Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary. [PDF]

PLoS ONE, 2022
Microtubule acetylation is found in populations of stable, long-lived microtubules, occurring on the conserved lysine 40 (K40) residue of α-tubulin by α-tubulin acetyltransferases (αTATs).
Matthew Antel, Taylor Simao, Muhammed Burak Bener, Mayu Inaba   +3 more
doaj   +2 more sources

Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection [PDF]

Journal of Virology
Microtubule acetylation, a post-translational modification catalyzing the addition of acetyl groups to lysine residues on alpha tubulin, confers mechanical resilience to microtubules and influences intracellular cargo transport.
Drew M. Lichon, Natalie J. LoMascolo, Bryan C. Mounce, Edward M. Campbell   +3 more
doaj   +2 more sources

Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition [PDF]

Cancer Cell International
Cyclin-dependent kinase 9 (CDK9) is a crucial component of transcription and potential target for anti-cancer therapies, particularly for hematological malignancies.
Xi Xie, Baoyuan Zhang, Donghe Li, Jiaming Gao, Jiaoyang Li, Chenxuan Liu, Yuqing Dan, Pengfei Xu, Lei Yan, Xu Huang, Rui Zhang, Yunying Yao, Wei Huang, Jiawei Nie, Xinru Wang, Bo Jiao, Ruibao Ren, Ping Liu   +17 more
doaj   +2 more sources

Microtubule damage shapes the acetylation gradient

Nature Communications
The properties of single microtubules within the microtubule network can be modulated through post-translational modifications (PTMs), including acetylation within the lumen of microtubules.
Charlotte Aumeier
exaly   +2 more sources

Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival [PDF]

Microbial Cell
Post-translational modifications of microtubules regulate their stability and dynamics. Acetylation of α tubulin at lysine 40 (K40) by α-acetyltransferase (αTAT) occurs on the luminal side of microtubules, stabilizes their structure, and plays essential ...
Thrishla Kumar, Katharina Röver, Johannes F. Stortz, Annika M. Binder, Benjamin Spreng, Madlen Konert, Markus Meissner, Friedrich Frischknecht, Elena Jimenez-Ruiz   +8 more
doaj   +2 more sources

Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress [PDF]

International Journal of Molecular Sciences, 2021
Panseon Ko, Jee-Hye Choi, Sangmyung Rhee   +2 more
exaly   +2 more sources

A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation [PDF]

Nature Communications
Centrosomes must undergo maturation in the G2/M phases to activate the microtubule-organizing activity, ensuring proper bipolar spindle assembly and chromosome segregation. Polo-like kinase 1(PLK1) is crucial for centrosome maturation. How the cell cycle
Jimin Li, Jianqiang Liang, Guifang Chen, Xuejie Wang, Yanyan Wang, Jingfei Zhan, Yunjing Guo, Jiadong Wang, Xuefeng Chen   +8 more
doaj   +2 more sources