Results 31 to 40 of about 21,311 (203)

Mitotic Acetylation of Microtubules Promotes Centrosomal PLK1 Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis

Cells, 2021
Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated ...
Sylvia Fenosoa Rasamizafy, Claude Delsert, Gabriel Rabeharivelo, Julien Cau, Nathalie Morin, Juliette van Dijk   +5 more
doaj   +1 more source

MYO1F regulates antifungal immunity by regulating acetylation of microtubules [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance Each year, the global mortality rates for fungal diseases now exceed those for malaria and breast cancer and are currently comparable to those for tuberculosis and HIV. The limited scope of currently available antifungal drugs is the major factor underlying the observed high mortality rate.
Wanwei Sun, Xiaojian Ma, Heping Wang, Yanyun Du, Jianwen Chen, Huijun Hu, Ru Gao, Ruirui He, Qianwen Peng, Zhihui Cui, Huazhi Zhang, Junhan Wang, Xinming Jia, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang   +16 more
openaire   +2 more sources

Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis

Cell Death Discovery, 2022
Gallbladder cancer is the most common biliary tract malignant tumor with highly metastatic characters and poor prognosis. However, the underlying mechanism remains unclear. Stathmin1 is ubiquitous phosphoprotein, regulating microtubule stabilization.
Kun Fan, Xiaojian Ni, Sheng Shen, Zijun Gong, Jiwen Wang, Yanlei Xin, Bohao Zheng, Wentao Sun, Han Liu, Tao Suo, Xiaoling Ni, Houbao Liu   +11 more
doaj   +1 more source

The TOG protein Stu2 is regulated by acetylation.

PLoS Genetics, 2022
Stu2 in S. cerevisiae is a member of the XMAP215/Dis1/CKAP5/ch-TOG family of MAPs and has multiple functions in controlling microtubules, including microtubule polymerization, microtubule depolymerization, linking chromosomes to the kinetochore, and ...
Matt A Greenlee, Braden Witt, Jeremy A Sabo, Savannah C Morris, Rita K Miller   +4 more
doaj   +1 more source

Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets

American Journal of Physiology - Renal Physiology, 2019
Jennifer L Groebner, Dean J Tūma
exaly   +2 more sources

Microtubules are acetylated in domains that turn over slowly [PDF]

Journal of Cell Science, 1989
ABSTRACT Tubulin is subject to a post-translational acetylation reaction that is thought to be correlated with increased stability of the modified microtubules (MTs). We sought to test directly the stability of acetylated MTs by determining their specific rate of turnover.
D R, Webster, G G, Borisy
openaire   +2 more sources

Acetylated microtubules are required for fusion of autophagosomes with lysosomes [PDF]

BMC Cell Biology, 2010
Abstract Background Autophagy is a dynamic process during which isolation membranes package substrates to form autophagosomes that are fused with lysosomes to form autolysosomes for degradation. Although it is agreed that the LC3II-associated mature autophagosomes move along microtubular tracks, it is still in dispute
Liu Leyuan, McKeehan Wallace L, Nguyen Susan, Xie Rui   +3 more
openaire   +3 more sources

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation. [PDF]

PLoS ONE, 2016
Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for ...
Todd J Cohen, Brian H Constance, Andrew W Hwang, Michael James, Chao-Xing Yuan   +4 more
doaj   +1 more source

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport. [PDF]

Sci Adv, 2019
peer reviewedMicrotubules are polymerized dimers of alpha- and beta-tubulin that underlie a broad range of cellular activities. Acetylation of alpha-tubulin by the acetyltransferase ATAT1 modulates microtubule dynamics and functions in neurons.
Even A, Morelli G, Broix L, Scaramuzzino C, Turchetto S, Gladwyn-Ng I, Le Bail R, Shilian M, Freeman S, Magiera MM, Jijumon AS, Krusy N, Malgrange B, Brone B, Dietrich P, Dragatsis I, Janke C, Saudou F, Weil M, Nguyen L.   +19 more
europepmc   +2 more sources

Regulation of cell migration by dynamic microtubules [PDF]

, 2011
Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility.
Irina Kaverina, Anne Straube, Kaverina, Irina, Straube, Anne   +3 more
core   +1 more source