Results 31 to 40 of about 21,416 (200)
Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation. [PDF]
PLoS ONE, 2016 Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for ...
Todd J Cohen +4 more
doaj +1 more source
Regulation of microtubule disassembly by spatially heterogeneous patterns of acetylation [PDF]
Soft Matter, 2019 This study investigates the effect of spatial patterns of acetylation on the disassembly dynamics of microtubule filaments using a multi-protofilament model.
Aparna J. S. +2 more
openaire +2 more sources
EWSR1 regulates mitosis by dynamically influencing microtubule acetylation. [PDF]
Cell Cycle, 2016 EWSR1, participating in transcription and splicing, has been identified as a translocation partner for various transcription factors, resulting in translocation, which in turn plays crucial roles in tumorigenesis. Recent studies have investigated the role of EWSR1 in mitosis. However, the effect of EWSR1 on mitosis is poorly understood.
Wang YL +7 more
europepmc +4 more sources
Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets
American Journal of Physiology - Renal Physiology, 2019 Jennifer L. Groebner, Dean J Tūma
exaly +2 more sources
Reduced microtubule acetylation in cystic fibrosis epithelial cells [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2013 Dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) leads to many cellular consequences, including perinuclear accumulation of free cholesterol due to impaired endosomal transport. The hypothesis being tested is that CF-related perinuclear cholesterol accumulation due to disrupted endocytic trafficking occurs as a result of reduced
Sharon M, Rymut +6 more
openaire +2 more sources
KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules [PDF]
Journal of Cell Science, 2009 Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been reported, including regulation of desmosome assembly, embryonic tissue morphogenesis and epidermal differentiation.
Nachat, Rachida +5 more
openaire +4 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Trypanosomatids have a cytoskeleton arrangement that is simpler than what is found in most eukaryotic cells. However, it is precisely organized and constituted by stable microtubules.
Victoria Lucia Alonso +13 more
doaj +1 more source
A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation [PDF]
Developmental Cell, 2008 Primary cilium dysfunction affects the development and homeostasis of many organs in Bardet-Biedl syndrome (BBS). We recently showed that seven highly conserved BBS proteins form a stable complex, the BBSome, that functions in membrane trafficking to and inside the primary cilium. We have now discovered a BBSome subunit that we named BBIP10. Similar to
Loktev, Alexander V. +9 more
openaire +2 more sources
Biomedicines, 2020 Microtubules are one of the major targets for anticancer drugs because of their role in cell proliferation and migration. However, as anticancer drugs targeting microtubules have side effects, including the death of normal cells, it is necessary to ...
Ahreum Kwon +9 more
doaj +1 more source
Microtubule Acetylation Promotes Kinesin-1 Binding and Transport [PDF]
Current Biology, 2006 Long-distance intracellular delivery is driven by kinesin and dynein motor proteins that ferry cargoes along microtubule tracks . Current models postulate that directional trafficking is governed by known biophysical properties of these motors-kinesins generally move to the plus ends of microtubules in the cell periphery, whereas cytoplasmic dynein ...
Reed, Nathan A. +6 more
openaire +2 more sources