Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation [PDF]
BMC Biology, 2018 Background Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimately released. Microtubule dynamics,
Juliette van Dijk +10 more
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αTAT1 catalyses microtubule acetylation at clathrin-coated pits [PDF]
Nature, 2013 In most eukaryotic cells microtubules undergo post-translational modifications such as acetylation of α-tubulin on lysine 40, a widespread modification restricted to a subset of microtubules that turns over slowly. This subset of stable microtubules accumulates in cell protrusions and regulates cell polarization, migration and invasion.
Jean-Christophe Olivo-Marin +2 more
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Effect of α-tubulin acetylation on the doublet microtubule structure
eLifeAcetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells.
Shun Kai Yang +8 more
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Redox Biology, 2021 The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD+-dependent deacetylase SIRT2 to regulate acetyl α-tubulin (K40) levels on microtubules. NQO1 catalyzes the oxidation of NADH to NAD+
David Siegel +2 more
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3D matrix stiffness drives energy metabolism to orchestrate stem cell osteogenesis via microtubule acetylation and mitochondrial dynamics [PDF]
Bioactive MaterialsHydrogels are widely recognized as promising materials for bone regeneration. However, how their biophysical properties, particularly stiffness, affect stem cell behavior in three-dimensional (3D) environments remains poorly understood.
Zhijie Yang +8 more
doaj +2 more sources
Targeting TTLL1 Alleviates Aβ-Induced Microtubule Disruption and TAU Pathology in Human iPSC-Derived Cortical Neurons [PDF]
PharmaceuticsBackground: Microtubules play a crucial role in neuronal structure and function, with their stability and dynamics regulated by posttranslational modifications (PTMs) such as polyglutamylation.
Mohamed Aghyad Al Kabbani +5 more
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S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux. [PDF]
Cells, 2021 Autophagy is a specific macromolecule and organelle degradation process. The target macromolecule or organelle is first enclosed in an autophagosome, and then delivered along acetylated microtubules to the lysosome. Autophagy is triggered by stress and largely contributes to cell survival.
Hać A +2 more
europepmc +5 more sources
Marginal band microtubules are acetylated by αTAT1 [PDF]
Platelets, 2020 The discoid shape of resting platelets is maintained by a peripheral, circular bundle of microtubules called marginal band. Marginal band microtubules are acetylated on lysine 40 of the alpha-tubulin subunits. We have previously shown that the deacetylase HDAC6 is responsible for tubulin deacetylation in platelets and that the hyperacetylated state of ...
Ribba, Anne-Sophie +9 more
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Microtubule acetylation and PERK activation facilitate eribulin-induced mitochondrial calcium accumulation and cell death [PDF]
Cellular and Molecular Life SciencesSung Hyun Kim +2 more
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Causes and Consequences of Microtubule Acetylation [PDF]
Current Biology, 2017 Among the different types of cytoskeletal components, microtubules arguably accumulate the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) of α-tubulin has received particular attention because it is the only tubulin PTM to be found in the lumen of microtubules: most other tubulin PTMs are found at the ...
Janke, Carsten, Montagnac, Guillaume
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