Results 11 to 20 of about 21,311 (203)

Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation [PDF]

BMC Biology, 2018
Background Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimately released. Microtubule dynamics,
Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, Julio Mateos-Langerak, Chantal Cazevieille, Patricia Cavelier, Brigitte Boizet-Bonhoure, Claude Delsert, Nathalie Morin   +10 more
doaj   +6 more sources

αTAT1 catalyses microtubule acetylation at clathrin-coated pits [PDF]

Nature, 2013
In most eukaryotic cells microtubules undergo post-translational modifications such as acetylation of α-tubulin on lysine 40, a widespread modification restricted to a subset of microtubules that turns over slowly. This subset of stable microtubules accumulates in cell protrusions and regulates cell polarization, migration and invasion.
Guillaume Montagnac, Vannary Meas-Yedid, Marie Irondelle   +2 more
exaly   +9 more sources

The ability to induce microtubule acetylation is a general feature of formin proteins. [PDF]

PLoS ONE, 2012
Cytoplasmic microtubules exist as distinct dynamic and stable populations within the cell. Stable microtubules direct and maintain cell polarity and it is thought that their stabilization is dependent on coordinative organization between the microtubule ...
Susan F Thurston, Wojciech A Kulacz, Sahir Shaikh, Jonathan M Lee, John W Copeland   +4 more
doaj   +5 more sources

Causes and Consequences of Microtubule Acetylation [PDF]

Current Biology, 2017
Among the different types of cytoskeletal components, microtubules arguably accumulate the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) of α-tubulin has received particular attention because it is the only tubulin PTM to be found in the lumen of microtubules: most other tubulin PTMs are found at the ...
Carsten, Janke, Guillaume, Montagnac
openaire   +4 more sources

Microtubule regulation: Transcending the tenet of K40 acetylation

Current Biology, 2022
For 36 years, the acetylation of lysine 40 in α-tubulin has provided the paradigm for how post-translational acetylation stabilises microtubules. A new study demonstrates that acetylation of lysine 394 in α-tubulin also mediates microtubule stabilisation in neurons.
Prokop, Andreas; id_orcid
openaire   +4 more sources

EWSR1 regulates mitosis by dynamically influencing microtubule acetylation. [PDF]

Cell Cycle, 2016
EWSR1, participating in transcription and splicing, has been identified as a translocation partner for various transcription factors, resulting in translocation, which in turn plays crucial roles in tumorigenesis. Recent studies have investigated the role of EWSR1 in mitosis. However, the effect of EWSR1 on mitosis is poorly understood.
Wang YL, Chen H, Zhan YQ, Yin RH, Li CY, Ge CH, Yu M, Yang XM.   +7 more
europepmc   +5 more sources

A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation [PDF]

Developmental Cell, 2008
Primary cilium dysfunction affects the development and homeostasis of many organs in Bardet-Biedl syndrome (BBS). We recently showed that seven highly conserved BBS proteins form a stable complex, the BBSome, that functions in membrane trafficking to and inside the primary cilium. We have now discovered a BBSome subunit that we named BBIP10. Similar to
Loktev, Alexander V., Zhang, Qihong, Beck, John S., Searby, Charles C., Scheetz, Todd E., Bazan, J. Fernando, Slusarski, Diane C., Sheffield, Val C., Jackson, Peter K., Nachury, Maxence V.   +9 more
openaire   +3 more sources

Microtubule Acetylation Promotes Kinesin-1 Binding and Transport [PDF]

Current Biology, 2006
Long-distance intracellular delivery is driven by kinesin and dynein motor proteins that ferry cargoes along microtubule tracks . Current models postulate that directional trafficking is governed by known biophysical properties of these motors-kinesins generally move to the plus ends of microtubules in the cell periphery, whereas cytoplasmic dynein ...
Reed, Nathan A., Cai, Dawen, Blasius, T. Lynne, Jih, Gloria T., Meyhofer, Edgar, Gaertig, Jacek, Verhey, Kristen J.   +6 more
openaire   +3 more sources

Effect of α-tubulin acetylation on the doublet microtubule structure

eLife
Acetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells.
Shun Kai Yang, Shintaroh Kubo, Corbin Steven Black, Katya Peri, Daniel Dai, Thibault Legal, Melissa Valente-Paterno, Jacek Gaertig, Khanh Huy Bui   +8 more
doaj   +3 more sources

Tubulin Acetylation Mediates Bisphenol A Effects on the Microtubule Arrays of Allium cepa and Triticum turgidum

Biomolecules, 2019
The effects of bisphenol A (BPA), a prevalent endocrine disruptor, on both interphase and mitotic microtubule array organization was examined by immunofluorescence microscopy in meristematic root cells of Triticum turgidum (durum wheat) and Allium cepa ...
Ioannis-Dimosthenis S. Adamakis, Emmanuel Panteris, Eleftherios P. Eleftheriou   +2 more
doaj   +2 more sources