Results 21 to 30 of about 21,416 (200)

DYRK1B regulates Hedgehog-induced microtubule acetylation. [PDF]

Cell Mol Life Sci, 2019
The posttranslational modification (PTM) of tubulin subunits is important for the physiological functions of the microtubule (MT) cytoskeleton. Although major advances have been made in the identification of enzymes carrying out MT-PTMs, little knowledge is available on how intercellular signaling molecules and their associated pathways regulate MT-PTM-
Singh R, Holz PS, Roth K, Hupfer A, Meissner W, Müller R, Buchholz M, Gress TM, Elsässer HP, Jacob R, Lauth M.   +10 more
europepmc   +3 more sources

Paclitaxel induces NM2-dependent cellular contraction through GEF-H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells. [PDF]

Mol Oncol
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Asensio-Juárez G, Pérez-Díaz R, Ramos-Solano H, Garrido-Casado M, Talayero VC, Vicente-Manzanares M.   +5 more
europepmc   +2 more sources

A Slow Dance for Microtubule Acetylation [PDF]

Cell, 2014
Microtubules contribute to diverse cellular processes through balancing dynamic, short-lived and stable, long-lived populations. One way in which long-lived microtubules are marked is by posttranslational acetylation of α-tubulin by tubulin acetyltransferase (TAT). Szyk et al.
Kull, F. Jon, Sloboda, Roger D.
openaire   +2 more sources

MYO1F regulates antifungal immunity by regulating acetylation of microtubules [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance Each year, the global mortality rates for fungal diseases now exceed those for malaria and breast cancer and are currently comparable to those for tuberculosis and HIV. The limited scope of currently available antifungal drugs is the major factor underlying the observed high mortality rate.
Wanwei Sun, Xiaojian Ma, Heping Wang, Yanyun Du, Jianwen Chen, Huijun Hu, Ru Gao, Ruirui He, Qianwen Peng, Zhihui Cui, Huazhi Zhang, Junhan Wang, Xinming Jia, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang   +16 more
openaire   +2 more sources

Coordination of microtubule acetylation and the actin cytoskeleton by formins. [PDF]

Cell Mol Life Sci, 2018
The acetylation of the lysine 40 residue of α-tubulin was described more than 30 years ago and has been the subject of intense research ever since. Although the exact function of this covalent modification of tubulin in the cell remains unknown, it has been established that tubulin acetylation confers resilience to mechanical stress on the microtubules.
Fernández-Barrera J, Alonso MA.
europepmc   +3 more sources

Mitotic Acetylation of Microtubules Promotes Centrosomal PLK1 Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis

Cells, 2021
Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated ...
Sylvia Fenosoa Rasamizafy, Claude Delsert, Gabriel Rabeharivelo, Julien Cau, Nathalie Morin, Juliette van Dijk   +5 more
doaj   +1 more source

Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis

Cell Death Discovery, 2022
Gallbladder cancer is the most common biliary tract malignant tumor with highly metastatic characters and poor prognosis. However, the underlying mechanism remains unclear. Stathmin1 is ubiquitous phosphoprotein, regulating microtubule stabilization.
Kun Fan, Xiaojian Ni, Sheng Shen, Zijun Gong, Jiwen Wang, Yanlei Xin, Bohao Zheng, Wentao Sun, Han Liu, Tao Suo, Xiaoling Ni, Houbao Liu   +11 more
doaj   +1 more source

Microtubules are acetylated in domains that turn over slowly [PDF]

Journal of Cell Science, 1989
ABSTRACT Tubulin is subject to a post-translational acetylation reaction that is thought to be correlated with increased stability of the modified microtubules (MTs). We sought to test directly the stability of acetylated MTs by determining their specific rate of turnover.
D R, Webster, G G, Borisy
openaire   +2 more sources

The TOG protein Stu2 is regulated by acetylation.

PLoS Genetics, 2022
Stu2 in S. cerevisiae is a member of the XMAP215/Dis1/CKAP5/ch-TOG family of MAPs and has multiple functions in controlling microtubules, including microtubule polymerization, microtubule depolymerization, linking chromosomes to the kinetochore, and ...
Matt A Greenlee, Braden Witt, Jeremy A Sabo, Savannah C Morris, Rita K Miller   +4 more
doaj   +1 more source

Acetylated microtubules are required for fusion of autophagosomes with lysosomes [PDF]

BMC Cell Biology, 2010
Abstract Background Autophagy is a dynamic process during which isolation membranes package substrates to form autophagosomes that are fused with lysosomes to form autolysosomes for degradation. Although it is agreed that the LC3II-associated mature autophagosomes move along microtubular tracks, it is still in dispute
Liu Leyuan, McKeehan Wallace L, Nguyen Susan, Xie Rui   +3 more
openaire   +3 more sources