Results 41 to 50 of about 21,416 (200)
Frontiers in Cell and Developmental Biology, 2020 Dynamic changes in microtubules during cell cycle progression are essential for spindle organization to ensure proper segregation of chromosomes. There is growing evidence that post translational modifications of tubulins are the key factors that ...
Hyuk-Joon Jeon, Jeong Su Oh
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Biomolecules, 2019 The effects of bisphenol A (BPA), a prevalent endocrine disruptor, on both interphase and mitotic microtubule array organization was examined by immunofluorescence microscopy in meristematic root cells of Triticum turgidum (durum wheat) and Allium cepa ...
Ioannis-Dimosthenis S. Adamakis +2 more
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Scientific Reports, 2021 Alzheimer’s disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. The insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed ...
Yuxing Xia +2 more
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Communications Biology, 2023 In response to nutritional stress, microtubules in cells of the Drosophila female germline are depleted from the cytoplasm and accumulate cortically. This triggers aggregation of mRNPs into large processing bodies (P-bodies) and oogenesis arrest.
Frank Wippich +3 more
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Acetylated microtubules let the ER slide [PDF]
Journal of Cell Biology, 2010 The endoplasmic reticulum (ER) slides along acetylated microtubules, possibly helping it to meet up with other organelles such as mitochondria, [Friedman et al.][1] report. ![Figure][2] The ER (green) slides along a stable microtubule (red).
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Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages
Frontiers in Immunology, 2019 Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome.
Qiong-zhen Zeng +9 more
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dTip60 HAT activity controls synaptic bouton expansion at the Drosophila neuromuscular junction. [PDF]
PLoS ONE, 2011 Histone acetylation of chromatin plays a key role in promoting the dynamic transcriptional responses in neurons that influence the neuroplasticity linked to cognitive ability, yet the specific histone acetyltransferases (HATs) that create such epigenetic
Jessica Sarthi, Felice Elefant
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The Effect of Tubulin Acetylation on Microtubule Structure and Dynamics [PDF]
Biophysical Journal, 2013 The post-translational acetylation of tubulin is a highly conserved process, but the effect of this modification on microtubule structure and function remains unclear. We have previously reported that the organization and localization of acetylated microtubules changes as epithelial cells undergo apico-basal polarization, suggesting that these ...
Joseph, Elavarasi +3 more
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Frontiers in PhysiologyThe innermost layer of the vessel wall is constantly subjected to recurring and relenting mechanical forces by virtue of their direct contact with blood flow.
Katiannah Moise +8 more
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Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]
PLoS ONE, 2016 Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang +6 more
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