Results 41 to 50 of about 21,311 (203)

Regulation of microtubule disassembly by spatially heterogeneous patterns of acetylation [PDF]

Soft Matter, 2019
This study investigates the effect of spatial patterns of acetylation on the disassembly dynamics of microtubule filaments using a multi-protofilament model.
Aparna J. S., Ranjith Padinhateeri, Dibyendu Das   +2 more
openaire   +2 more sources

Reduced microtubule acetylation in cystic fibrosis epithelial cells [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2013
Dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) leads to many cellular consequences, including perinuclear accumulation of free cholesterol due to impaired endosomal transport. The hypothesis being tested is that CF-related perinuclear cholesterol accumulation due to disrupted endocytic trafficking occurs as a result of reduced
Sharon M, Rymut, Alyssa, Harker, Deborah A, Corey, James D, Burgess, Hongtao, Sun, John P, Clancy, Thomas J, Kelley   +6 more
openaire   +2 more sources

KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules [PDF]

Journal of Cell Science, 2009
Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been reported, including regulation of desmosome assembly, embryonic tissue morphogenesis and epidermal differentiation.
Nachat, Rachida, Cipolat, Sara, Sevilla, Lisa M, Chhatriwala, Mariya, Groot, Karen R, Watt, Fiona M   +5 more
openaire   +4 more sources

Alpha-Tubulin Acetylation in Trypanosoma cruzi: A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosomatids have a cytoskeleton arrangement that is simpler than what is found in most eukaryotic cells. However, it is precisely organized and constituted by stable microtubules.
Victoria Lucia Alonso, Victoria Lucia Alonso, Mara Emilia Carloni, Camila Silva Gonçalves, Camila Silva Gonçalves, Gonzalo Martinez Peralta, Gonzalo Martinez Peralta, Maria Eugenia Chesta, Alejandro Pezza, Luis Emilio Tavernelli, Maria Cristina M. Motta, Maria Cristina M. Motta, Esteban Serra, Esteban Serra   +13 more
doaj   +1 more source

Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer

Biomedicines, 2020
Microtubules are one of the major targets for anticancer drugs because of their role in cell proliferation and migration. However, as anticancer drugs targeting microtubules have side effects, including the death of normal cells, it is necessary to ...
Ahreum Kwon, Gwi Bin Lee, Taein Park, Jung Hoon Lee, Panseon Ko, Eunae You, Jin Hee Ahn, Soo Hyun Eom, Sangmyung Rhee, Woo Keun Song   +9 more
doaj   +1 more source

Modulating microtubule stability via α-tubulin acetylation partially restores Golgi fragmentation in spinal muscular atrophy. [PDF]

Turk J Biol
Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in ...
Zobaroğlu Özer P, Gözüböyük M, Çetin Ö, Hensel N, Emecen G, Malik A, Bowerman M, Claus P, Erdem Yurter H, Bora Akoğlu G.   +9 more
europepmc   +2 more sources

RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes

Frontiers in Cell and Developmental Biology, 2020
Dynamic changes in microtubules during cell cycle progression are essential for spindle organization to ensure proper segregation of chromosomes. There is growing evidence that post translational modifications of tubulins are the key factors that ...
Hyuk-Joon Jeon, Jeong Su Oh
doaj   +1 more source

A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation

Redox Biology, 2021
The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD+-dependent deacetylase SIRT2 to regulate acetyl α-tubulin (K40) levels on microtubules. NQO1 catalyzes the oxidation of NADH to NAD+
David Siegel, Stephanie Bersie, Peter Harris, Andrea Di Francesco, Michael Armstrong, Nichole Reisdorph, Michel Bernier, Rafael de Cabo, Kristofer Fritz, David Ross   +9 more
doaj   +1 more source

Ectopic A-lattice seams destabilize microtubules [PDF]

, 2014
Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability.
Cross, R. A., Katsuki, Miho, Drummond, Douglas R.   +2 more
core   +1 more source

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

Scientific Reports, 2021
Alzheimer’s disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. The insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed ...
Yuxing Xia, Brach M. Bell, Benoit I. Giasson   +2 more
doaj   +1 more source