Results 51 to 60 of about 21,311 (203)

Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation

Communications Biology, 2023
In response to nutritional stress, microtubules in cells of the Drosophila female germline are depleted from the cytoplasm and accumulate cortically. This triggers aggregation of mRNPs into large processing bodies (P-bodies) and oogenesis arrest.
Frank Wippich, Vaishali, Marco L. Hennrich, Anne Ephrussi   +3 more
doaj   +1 more source

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. [PDF]

, 2010
Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function.
Mulvihill, Daniel P., Arthur T. Coulton, East, Daniel A., Coulton, Arthur T., Lehman, William, William Lehman, Daniel A. East, Daniel P. Mulvihill, Galinska-Rakoczy, Agnieszka, Agnieszka Galinska-Rakoczy   +9 more
core   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

Angewandte Chemie, EarlyView.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni, Jessica Groppi, Alberto Credi, Serena Silvi   +3 more
wiley   +2 more sources

Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages

Frontiers in Immunology, 2019
Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome.
Qiong-zhen Zeng, Fan Yang, Chen-guang Li, Li-hui Xu, Xian-hui He, Feng-yi Mai, Chen-ying Zeng, Cheng-cheng Zhang, Qing-bing Zha, Dong-yun Ouyang   +9 more
doaj   +1 more source

dTip60 HAT activity controls synaptic bouton expansion at the Drosophila neuromuscular junction. [PDF]

PLoS ONE, 2011
Histone acetylation of chromatin plays a key role in promoting the dynamic transcriptional responses in neurons that influence the neuroplasticity linked to cognitive ability, yet the specific histone acetyltransferases (HATs) that create such epigenetic
Jessica Sarthi, Felice Elefant
doaj   +1 more source

Acetylated microtubules let the ER slide [PDF]

Journal of Cell Biology, 2010
The endoplasmic reticulum (ER) slides along acetylated microtubules, possibly helping it to meet up with other organelles such as mitochondria, [Friedman et al.][1] report. ![Figure][2] The ER (green) slides along a stable microtubule (red).
openaire   +1 more source

Microtubule acetylation induced by expression of formin FH1FH2 derivatives.

, 2012
FH1–FH2 containing formin derivatives were expressed in NIH 3T3 fibroblasts by transient transfection. Their effects on microtubule acetylation were assessed by immunofluorescence. A) Expression of Dia 1 (red, left panel) induces microtubule acetylation (
John W. Copeland (126876), Jonathan M. Lee (126875), Susan F. Thurston (126872), Wojciech A. Kulacz (126873), Sahir Shaikh (126874)   +4 more
core   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

, 2014
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian, Pestell, RG0, Fuqua, Suzanne A W, Wang, Chenguang, Yeung, YG, Hopp, Torsten, Jaffray, E, Chang, Chawnshang, Fu, Maofu, Sakamaki, Toshiyuki, Janne, OA, Zhang, Xueping, Hay, Ronald Thomas, Palvimo, Jorma J   +13 more
core   +1 more source

Endothelial cell elongation and alignment in response to shear stress requires acetylation of microtubules

Frontiers in Physiology
The innermost layer of the vessel wall is constantly subjected to recurring and relenting mechanical forces by virtue of their direct contact with blood flow.
Katiannah Moise, Keerthana M. Arun, Maalavika Pillai, Maalavika Pillai, Jocelynda Salvador, Aarya S. Mehta, Yogesh Goyal, Yogesh Goyal, M. Luisa Iruela-Arispe   +8 more
doaj   +1 more source

Molecular Basis for Age-Dependent Microtubule Acetylation [PDF]

Biophysical Journal, 2015
Microtubules are decorated with chemically diverse and evolutionarily conserved posttranslational modifications that mark them for specialized functions in cells. Other than viruses and clathrin cages, microtubules are the only known hollow polymers in eukaryotic cells.
Roll-Mecak, Antonina, Szyk, Agnieszka, Deaconescu, Alexandra, Spector, Jeffrey, Valenstein, Max, Grigorieff, Niko   +5 more
openaire   +1 more source