Results 61 to 70 of about 21,416 (200)
Microtubule Modification: Acetylation Speeds Anterograde Traffic Flow [PDF]
Current Biology, 2007 Microtubules in neurites undergo multiple post-translational modifications. Recent work shows that neurites enriched in acetylated microtubules selectively support kinesin-mediated transport of the JNK regulator JIP-1 to growth cones.
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Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase [PDF]
Cell, 2014 Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known posttranslational modification in the microtubule lumen. It marks stable microtubules and is required for polarity establishment and directional migration. Here, we elucidate the mechanistic underpinnings for TAT activity and its preference for microtubules with slow ...
Szyk, Agnieszka +8 more
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Disease Models & Mechanisms, 2017 Tau normally associates with and stabilizes microtubules (MTs), but is hyperphosphorylated and aggregated into neurofibrillary tangles in Alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies.
Chuan-Xi Mao +3 more
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Scientific Reports, 2023 Microtubule dysfunction has been implicated as a mediator of inflammation in multiple diseases such as disorders of the cardiovascular and neurologic systems.
Tori Endres +3 more
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Advanced Science, EarlyView.Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu +12 more
wiley +1 more source
Submembraneous microtubule cytoskeleton: regulation of ATPases by interaction with acetylated tubulin [PDF]
The FEBS Journal, 2008 The ATP‐hydrolysing enzymes (Na+,K+)‐, H+‐ and Ca2+‐ATPase are integral membrane proteins that play important roles in the exchange of ions and nutrients between the exterior and interior of cells, and are involved in signal transduction pathways. Activity of these ATPases is regulated by several specific effectors.
Arce, Carlos Angel +2 more
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Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. [PDF]
PLoS ONE, 2015 The centrosomal protein, CDK5RAP2, is a microcephaly protein that regulates centrosomal maturation by recruitment of a γ-tubulin ring complex (γ-TuRC) onto centrosomes. In this report, we identified a novel human centrosomal protein, Cep169, as a binding
Yusuke Mori +6 more
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Advanced Science, EarlyView.This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu +9 more
wiley +1 more source
Microbial CellPost-translational modifications of microtubules regulate their stability and dynamics. Acetylation of α tubulin at lysine 40 (K40) by α-acetyltransferase (αTAT) occurs on the luminal side of microtubules, stabilizes their structure, and plays essential ...
Thrishla Kumar +8 more
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Scientific Reports, 2021 Factor quinolinone inhibitors are promising anti-cancer compounds, initially characterized as specific inhibitors of the oncogenic transcription factor LSF (TFCP2).
Patrick Stoiber +6 more
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