Results 61 to 70 of about 21,311 (203)

The Effect of Tubulin Acetylation on Microtubule Structure and Dynamics [PDF]

Biophysical Journal, 2013
The post-translational acetylation of tubulin is a highly conserved process, but the effect of this modification on microtubule structure and function remains unclear. We have previously reported that the organization and localization of acetylated microtubules changes as epithelial cells undergo apico-basal polarization, suggesting that these ...
Joseph, Elavarasi, Quinones, Gerri, Singh, Vimla, Ligon, Lee   +3 more
openaire   +1 more source

The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model

Frontiers in Neuroscience, 2018
Axon degeneration has been implicated as a pathological process in several neurodegenerative diseases and acquired forms of neural injury. We have previously shown that stabilizing microtubules can protect axons against excitotoxin-induced fragmentation,
Kelsey Hanson, Nan Tian, James C. Vickers, Anna E. King   +3 more
doaj   +1 more source

Tubulin acetylation alone does not affect kinesin-1 velocity and run length in vitro. [PDF]

PLoS ONE, 2012
Kinesin-1 plays a major role in anterograde transport of intracellular cargo along microtubules. Currently, there is an ongoing debate of whether α-tubulin K40 acetylation directly enhances the velocity of kinesin-1 and its affinity to the microtubule ...
Wilhelm J Walter, Václav Beránek, Elisabeth Fischermeier, Stefan Diez   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Agrin promotes acetylcholine receptor clustering at the mammalian neuro-muscular junction by PI3K/GSK3ß²-mediated regulation of +TIPs and microtubule capture [PDF]

, 2013
Neurotransmission an der neuromuskulären Endplatte von Säugetieren erfolgt durch Ausschüttung von Acetylcholin (ACh) aus motorischen Nerven in den synaptischen Spalt und verursacht letztendlich Muskelkontraktion im angesteuerten Muskel.
Sladecek, Stefan
core   +1 more source

Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization

Cell Death Discovery, 2021
The posttranslational modifications (PTMs) of microtubules have been reported to play an important role in cancer aggressiveness, including apoptosis resistance.
Onsurang Wattanathamsan, Rawikorn Thararattanobon, Ratchanee Rodsiri, Pithi Chanvorachote, Chanida Vinayanuwattikun, Varisa Pongrakhananon   +5 more
doaj   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

Advanced Functional Materials, EarlyView.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough, Roy Chen, Katerina Katsouleas, Jaron Shoemaker, Travis Brady, Tianfang Yu, Jennifer Arthur Ataam, Connor Amelung, Lakshmi Santhanam, Ioannis Karakikes, Sharon Gerecht   +10 more
wiley   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Microtubule Modification: Acetylation Speeds Anterograde Traffic Flow [PDF]

Current Biology, 2007
Microtubules in neurites undergo multiple post-translational modifications. Recent work shows that neurites enriched in acetylated microtubules selectively support kinesin-mediated transport of the JNK regulator JIP-1 to growth cones.
openaire   +2 more sources

Dispensability of tubulin acetylation for 15-protofilament microtubule formation in the mammalian cochlea. [PDF]

, 2021
peer reviewedThe development of hearing in mammals requires the formation and maturation of a highly organized and specialized epithelium known as the organ of Corti.
Thiry, Marc, Renauld, Justine, Bartholomé, Odile, Malgrange, Brigitte, Thelen, Nicolas   +4 more
core   +1 more source