Results 81 to 90 of about 21,311 (203)
The deacetylase HDAC6 is an essential component of stress granules and plays a critical role in the cellular response to stress [PDF]
, 2007 The reversible acetylation of histones has a critical role in transcriptional regulation. Likewise reversible acetylation of non-histones proteins is also important for other cellular processes.
Kwon, So Hee
core +1 more source
Scientific Reports, 2021 Factor quinolinone inhibitors are promising anti-cancer compounds, initially characterized as specific inhibitors of the oncogenic transcription factor LSF (TFCP2).
Patrick Stoiber +6 more
doaj +1 more source
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Submembraneous microtubule cytoskeleton: regulation of ATPases by interaction with acetylated tubulin [PDF]
The FEBS Journal, 2008 The ATP‐hydrolysing enzymes (Na+,K+)‐, H+‐ and Ca2+‐ATPase are integral membrane proteins that play important roles in the exchange of ions and nutrients between the exterior and interior of cells, and are involved in signal transduction pathways. Activity of these ATPases is regulated by several specific effectors.
Arce, Carlos Angel +2 more
openaire +3 more sources
The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly
Advanced Science, EarlyView.Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie +20 more
wiley +1 more source
Cell Death Discovery, 2021 Acetylation of α-tubulin lysine 40 (αK40) contributes to microtubule (MT) stability and is essential for neuronal development and function, whereas excessive αK40 deacetylation is observed in neurodegenerative disorders including Alzheimer’s disease (AD).
Taegwan Yun +6 more
doaj +1 more source
Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts [PDF]
The Journal of Neuroscience, 2010 Here we investigated whether the sensitivity of microtubules to severing by katanin is regulated by acetylation of the microtubules. During interphase, fibroblasts display long microtubules with discrete regions rich in acetylated tubulin. Overexpression of katanin for short periods of time produced breaks preferentially in these regions.
Haruka, Sudo, Peter W, Baas
openaire +2 more sources
TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells
EMBO Reports, 2023 The primary cilium is a critical sensory organelle that is built of axonemal microtubules ensheathed by a ciliary membrane. In polarized epithelial cells, primary cilia reside on the apical surface and must extend these microtubules directly into the ...
Julia Ceglowski +6 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Abnormal aggregation of the microtubule-associated protein Tau is closely associated with tauopathies, including Alzheimer’s disease and chronic traumatic encephalopathy.
Yu Zou, Lulu Guan
doaj +1 more source
Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. [PDF]
PLoS ONE, 2013 The Tat protein of HIV-1 has several well-known properties, such as nucleocytoplasmic trafficking, transactivation of transcription, interaction with tubulin, regulation of mitotic progression, and induction of apoptosis. Previous studies have identified
Minghao He +11 more
doaj +1 more source