Results 71 to 80 of about 21,416 (200)

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Modifications of Lysine Residues 294 and 311 Within the Microtubule‐Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria

Angewandte Chemie, EarlyView.
The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl, Mario Migotti, Robert Konrat, Anne C. Conibear, Christian F. W. Becker   +4 more
wiley   +2 more sources

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin

Cell Death Discovery, 2021
Acetylation of α-tubulin lysine 40 (αK40) contributes to microtubule (MT) stability and is essential for neuronal development and function, whereas excessive αK40 deacetylation is observed in neurodegenerative disorders including Alzheimer’s disease (AD).
Taegwan Yun, Hyo Rim Ko, Dong-Kyu Jo, Kye Won Park, Sung-Woo Cho, Jihoe Kim, Jee-Yin Ahn   +6 more
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts [PDF]

The Journal of Neuroscience, 2010
Here we investigated whether the sensitivity of microtubules to severing by katanin is regulated by acetylation of the microtubules. During interphase, fibroblasts display long microtubules with discrete regions rich in acetylated tubulin. Overexpression of katanin for short periods of time produced breaks preferentially in these regions.
Haruka, Sudo, Peter W, Baas
openaire   +2 more sources

TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells

EMBO Reports, 2023
The primary cilium is a critical sensory organelle that is built of axonemal microtubules ensheathed by a ciliary membrane. In polarized epithelial cells, primary cilia reside on the apical surface and must extend these microtubules directly into the ...
Julia Ceglowski, Huxley K Hoffman, Andrew J Neumann, Katie J Hoff, Bailey L McCurdy, Jeffrey K Moore, Rytis Prekeris   +6 more
doaj   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure [PDF]

Molecular Biology of the Cell, 2014
Tubulin undergoes posttranslational modifications proposed to specify microtubule subpopulations for particular functions. Most of these modifications occur on the C-termini of tubulin and may directly affect the binding of microtubule-associated proteins (MAPs) or motors.
Howes, Stuart C, Alushin, Gregory M, Shida, Toshinobu, Nachury, Maxence V, Nogales, Eva   +4 more
openaire   +3 more sources