Results 71 to 80 of about 21,311 (203)
βPix-d promotes tubulin acetylation and neurite outgrowth through a PAK/Stathmin1 signaling pathway.
PLoS ONE, 2020 Microtubules are a major cytoskeletal component of neurites, and the regulation of microtubule stability is essential for neurite morphogenesis. βPix (ARHGEF7) is a guanine nucleotide exchange factor for the small GTPases Rac1 and Cdc42, which modulate ...
Younghee Kwon +5 more
doaj +1 more source
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Microtubule Acetylation in Anterior Pituitary Gonadotropes
, 2016 The hypothalamic pituitary gonadal (HPG) axis plays an essential role in mammalian reproduction. In the hypothalamus gonadotropin releasing hormone (GnRH) is released where it then travels to the anterior pituitary to bind to its receptor on gonadotrope ...
JayCee Mikesell (10086289)
core +1 more source
Scientific Reports, 2023 Microtubule dysfunction has been implicated as a mediator of inflammation in multiple diseases such as disorders of the cardiovascular and neurologic systems.
Tori Endres +3 more
doaj +1 more source
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
The Role of Microtubule End Structure in Microtubule Acetylation and Dynamics [PDF]
, 2016 University of Minnesota Ph.D. dissertation July 2016. Major: Biology. Advisor: Melissa Gardner. 1 computer file (PDF); vii, 116 pages.Microtubules are long hollow filaments that have the striking ability to restructure themselves.
Coombes, Courtney
core
A phospho-regulated ensemble signal motif of α-TAT1 drives dynamic microtubule acetylation
, 2021 Posté le 5 décembre 2020 sur BioRxivSpatiotemporal patterns of microtubule modifications such as acetylation underlie diverse cellular functions. While the molecular identity of the acetylating agent, α-tubulin N-acetyltransferase 1 (α-TAT1), as well as ...
Deb Roy, Abhijit +5 more
core +1 more source
Disease Models & Mechanisms, 2017 Tau normally associates with and stabilizes microtubules (MTs), but is hyperphosphorylated and aggregated into neurofibrillary tangles in Alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies.
Chuan-Xi Mao +3 more
doaj +1 more source
Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. [PDF]
PLoS ONE, 2015 The centrosomal protein, CDK5RAP2, is a microcephaly protein that regulates centrosomal maturation by recruitment of a γ-tubulin ring complex (γ-TuRC) onto centrosomes. In this report, we identified a novel human centrosomal protein, Cep169, as a binding
Yusuke Mori +6 more
doaj +1 more source
Advanced Science, EarlyView.PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang +10 more
wiley +1 more source