Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons [PDF]
Biomolecules, 2023 An important post-translational modification (PTM) of α-tubulin is the removal of amino acids from its C-terminus. Removal of the C-terminal tyrosine residue yields detyrosinated α-tubulin, and subsequent removal of the penultimate glutamate residue ...
Takashi Hotta +8 more
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α-tubulin detyrosination fine-tunes kinetochore-microtubule attachments [PDF]
Nature CommunicationsPost-translational cycles of α-tubulin detyrosination and tyrosination generate microtubule diversity, the cellular functions of which remain largely unknown.
Hugo Girão +10 more
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Cryo-EM of α-tubulin isotype-containing microtubules revealed a contracted structure of α4A/β2A microtubules [PDF]
Acta Biochimica et Biophysica Sinica, 2023 Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells. In vertebrates, both α- and β-tubulins have multiple isotypes encoded by different genes, which are intrinsic factors in
Diao Lei +7 more
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Reduced acetylated α-tubulin in SPAST hereditary spastic paraplegia patient PBMCs [PDF]
Frontiers in Neuroscience, 2023 HSP-SPAST is the most common form of hereditary spastic paraplegia (HSP), a neurodegenerative disease causing lower limb spasticity. Previous studies using HSP-SPAST patient-derived induced pluripotent stem cell cortical neurons have shown that patient ...
Gautam Wali +14 more
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Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation [PDF]
eLifeMicrotubules are cytoskeletal filaments that self-assemble from the protein tubulin, a heterodimer of α-tubulin and β-tubulin, and are important for cell mechanics, migration, and division.
Takashi Hotta +12 more
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Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation [PDF]
Nature CommunicationsPosttranslational modifications (PTMs) of tubulin, termed the “tubulin code”, play important roles in regulating microtubule functions within subcellular compartments for specialized cellular activities.
Shuangshuang Sun +12 more
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Molecular Docking of Cryptoconcatones to α-Tubulin and Related Pironetin Analogues [PDF]
Plants, 2023 Cryptoconcatones A-L represent a series of 12 dihydropyrone derivatives isolated from the evergreen tree Cryptocarya concinna Hance, which is well distributed in southeast Asia.
Gérard Vergoten, Christian Bailly
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Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation [PDF]
Communications Biology, 2023 In response to nutritional stress, microtubules in cells of the Drosophila female germline are depleted from the cytoplasm and accumulate cortically. This triggers aggregation of mRNPs into large processing bodies (P-bodies) and oogenesis arrest.
Frank Wippich +3 more
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Targeting plasmodium α-tubulin-1 to block malaria transmission to mosquitoes [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Plasmodium ookinetes use an invasive apparatus to invade mosquito midguts, and tubulins are the major structural proteins of this apical complex. We examined the role of tubulins in malaria transmission to mosquitoes.
Genwei Zhang +10 more
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Linking acetylated α-Tubulin redistribution to α-Synuclein pathology in brain of Parkinson’s disease patients [PDF]
npj Parkinson's DiseaseHighly specialized microtubules in neurons are crucial to both health and disease of the nervous system, and their properties are strictly regulated by different post-translational modifications, including α-Tubulin acetylation.
Samanta Mazzetti +12 more
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