Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation [PDF]
Communications Biology, 2023 In response to nutritional stress, microtubules in cells of the Drosophila female germline are depleted from the cytoplasm and accumulate cortically. This triggers aggregation of mRNPs into large processing bodies (P-bodies) and oogenesis arrest.
Frank Wippich +3 more
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Vimentin inhibits α-tubulin acetylation via enhancing α-TAT1 degradation to suppress the replication of human parainfluenza virus type 3. [PDF]
PLoS Pathogens, 2022 We previously found that, among human parainfluenza virus type 3 (HPIV3) proteins, the interaction of nucleoprotein (N) and phosphoprotein (P) provides the minimal requirement for the formation of cytoplasmic inclusion bodies (IBs), which are sites of ...
Pengfei Liu +5 more
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MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A [PDF]
iScienceSummary: Mitofusin-2 (MFN2), a large GTPase residing in the mitochondrial outer membrane and mutated in Charcot-Marie-Tooth type 2 disease (CMT2A), is a regulator of mitochondrial fusion and tethering with the ER.
Atul Kumar +10 more
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Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation [PDF]
Frontiers in Pharmacology, 2019 Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the underlying mechanism is unclear.
Chen-Guang Li +8 more
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TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite
mSphere, 2016 Toxoplasma gondii is a widespread protozoan parasite that causes potentially life-threatening opportunistic disease. New inhibitors of parasite replication are urgently needed, as the current antifolate treatment is also toxic to patients.
Joseph M. Varberg +3 more
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Effect of α-tubulin acetylation on the doublet microtubule structure [PDF]
eLifeAcetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells.
Shun Kai Yang +8 more
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SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation [PDF]
Biology DirectAdvanced paternal age compromises male fertility and correlates to a decline of the deacetylase SIRT1 activity, a central regulator of germline homeostasis and chromatin dynamics. Acetylation imbalance has been pointed out as a driver of testicular aging.
María Iniesta-Cuerda +6 more
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Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival [PDF]
Microbial CellPost-translational modifications of microtubules regulate their stability and dynamics. Acetylation of α tubulin at lysine 40 (K40) by α-acetyltransferase (αTAT) occurs on the luminal side of microtubules, stabilizes their structure, and plays essential ...
Thrishla Kumar +8 more
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Frontiers in Cellular and Infection Microbiology, 2021 Trypanosomatids have a cytoskeleton arrangement that is simpler than what is found in most eukaryotic cells. However, it is precisely organized and constituted by stable microtubules.
Victoria Lucia Alonso +13 more
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Microtubule acetylation dyshomeostasis in Parkinson’s disease
Translational Neurodegeneration, 2023 The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system.
Padmashri Naren +6 more
doaj +1 more source