Results 11 to 20 of about 1,007,835 (176)

Microtubule lattice conformation and integrity regulate α-tubulin acetylation [PDF]

Communications Biology
Microtubule acetylation of lysine 40 of α-tubulin is a hallmark of stable microtubules. This luminal modification is catalyzed by α-tubulin acetyltransferase 1 (αTAT1) and reversed by histone deacetylase 6 (HDAC6).
Cornelia Egoldt, Marie-Claire Velluz, Joshua Tran, Charlotte Aumeier   +3 more
doaj   +3 more sources

TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii [PDF]

mSphere, 2016
Toxoplasma gondii is a widespread protozoan parasite that causes potentially life-threatening opportunistic disease. New inhibitors of parasite replication are urgently needed, as the current antifolate treatment is also toxic to patients.
Joseph M. Varberg, Leah R. Padgett, Gustavo Arrizabalaga, William J. Sullivan   +3 more
doaj   +5 more sources

Expression of α-Tubulin Acetyltransferase 1 and Tubulin Acetylation as Selective Forces in Cell Competition

Cells, 2021
The wound healing response of fibroblasts critically depends on the primary cilium, a sensory organelle protruding into the environment and comprising a stable axonemal structure.
Sigrid Hoyer-Fender, Constanza Tapia Contreras, İrem Kılıç   +2 more
exaly   +4 more sources

Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients

Platelets, 2023
Platelet inhibition is the main treatment strategy to prevent atherothrombotic complications after acute coronary syndrome or percutaneous coronary intervention.
Valentine Robaux, Shakeel Kautbally, Audrey Ginion, Mélanie Dechamps, Sibille Lejeune, Nassiba Menghoum, Luc Bertrand, Anne-Catherine Pouleur, Sandrine Horman, Christophe Beauloye   +9 more
doaj   +2 more sources

Effect of α-tubulin acetylation on the doublet microtubule structure [PDF]

eLife
Acetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells.
Shun Kai Yang, Shintaroh Kubo, Corbin Steven Black, Katya Peri, Daniel Dai, Thibault Legal, Melissa Valente-Paterno, Jacek Gaertig, Khanh Huy Bui   +8 more
doaj   +2 more sources

Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules. [PDF]

PLoS ONE, 2012
The αβ-tubulin subunits of microtubules can undergo a variety of evolutionarily-conserved post-translational modifications (PTMs) that provide functional specialization to subsets of cellular microtubules. Acetylation of α-tubulin residue Lysine-40 (K40)
Virupakshi Soppina, Jeffrey F Herbstman, Georgios Skiniotis, Kristen J Verhey   +3 more
doaj   +2 more sources

Ethanol Administration in Mice Leads to Sex-Specific Changes in the Acetylation of α-Tubulin in the Cerebellum

Brain Sciences
Background: Acetylation of α-tubulin is an important post-translational modification that helps maintain microtubules’ stability and dynamics, including axonal transport, cell signaling, and overall neuronal integrity.
Tibor Kristian, Junfang Wu
exaly   +3 more sources

Effects of α-tubulin acetylation on microtubule structure and stability [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Lisa Eshun-Wilson, Eva Nogales, Didier Portran   +2 more
exaly   +2 more sources

Modulating microtubule stability via α-tubulin acetylation partially restores Golgi fragmentation in spinal muscular atrophy. [PDF]

Turk J Biol
Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in ...
Zobaroğlu Özer P, Gözüböyük M, Çetin Ö, Hensel N, Emecen G, Malik A, Bowerman M, Claus P, Erdem Yurter H, Bora Akoğlu G.   +9 more
europepmc   +2 more sources

The role of α-tubulin acetylation in the regulation of murine sperm motility [PDF]

, 2019
Sperm motility is a vital function required for fertility and is a consequence of interactions between components of the axoneme in the sperm flagellum. Microtubules, made up of α and β-tubulin, are a central component of the axoneme and undergo various
FRANCIS, SARAH,LOUISE
core   +6 more sources