Results 101 to 110 of about 1,093,472 (256)

Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition

Cancer Cell International
Cyclin-dependent kinase 9 (CDK9) is a crucial component of transcription and potential target for anti-cancer therapies, particularly for hematological malignancies.
Xi Xie, Baoyuan Zhang, Donghe Li, Jiaming Gao, Jiaoyang Li, Chenxuan Liu, Yuqing Dan, Pengfei Xu, Lei Yan, Xu Huang, Rui Zhang, Yunying Yao, Wei Huang, Jiawei Nie, Xinru Wang, Bo Jiao, Ruibao Ren, Ping Liu   +17 more
doaj   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

MOESM2 of A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin

, 2019
Additional file 2: Figure S2. Alterations of mitotic spindle structure, cell cycle progression and apoptosis in SW620 cells. (A) SW620 cells were treated with 80 µM 3,4,4′-TMS for 2 h, fixed and stained with anti-α-tubulin and anti-γ-tubulin antibodies ...
Zulema Percario (6574118), Francesca Degrassi (231524), Daniela Trisciuoglio (132747), Renata Cozzi (651264), Gianandrea Traversi (6574112), David Staid (6574115), Veronica Morea (1495819), Mario Fiore (231517), Roberto Antonioletti (201575)   +8 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

stai Mutants Have Reduced Levels of α-Tubulin, Acetylated α-Tubulin, and Kinesin Heavy Chain Protein.

, 2013
(A) Representative western blots of total protein extracted from stai mutant third instar larvae. Heterozygous stai/+ mutant larvae exhibit mild reductions in the levels of α-tubulin and acetylated α-tubulin compared with wild type larvae.
Alfredo Zuniga (426937), Jason E. Duncan (426935), Nikki K. Lytle (426936), Lawrence S. B. Goldstein (187928)   +3 more
core   +1 more source

Integrative AI-assisted modeling suggests CPPF binding at a composite α/β-tubulin interface pocket dominated by β-tubulin contacts.

PLoS Computational Biology
Microtubules are dynamic cytoskeletal polymers assembled from α/β-tubulin heterodimers. Microtubules are validated targets for novel therapeutic drugs, yet therapeutic efficacy targeting them is often compromised by multidrug resistance (MDR).
Jixin Yang, Lisha Liang, Dengchao Zhu, Xuzhe Yin, Yizhuo Feng, Shaojun Tang, Muzi Li   +6 more
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Isolation of functional tubulin dimers and of tubulin-associated proteins from mammalian cells

, 2016
The microtubule (MT) cytoskeleton forms a dynamic filamentous network that is essential for many processes, including mitosis, cell polarity and shape, neurite outgrowth and migration, and ciliogenesis [1, 2]. MTs are built up of α/β-tubulin heterodimers,
Signorile, L., Leslie, K., Ottema, Sophie, Lebbink, J., Lebbink, Joyce, Galjart, N., Smal, I., Ottema, S., Leslie, Kris, Demmers, Jeroen, Yuill, N., Yu, Nuo, Signorile, Luca, Galjart, Niels; id_orcid, Galjart, Niels, Dekkers, D., Smal, Ihor, Basu, S., Basu, Sreya, Demmers, J., Dekkers, Dick   +20 more
core   +1 more source

A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin [PDF]

, 2019
Background: Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generation of new analogues with improved
Zulema Percario (6574118), Francesca Degrassi (231524), Veronica Morea, Gianandrea Traversi, Zulema Percario, Veronica Morea (1495819), David Sasah Staid, Mario Fiore, Roberto Antonioletti (201575), Renata Cozzi, Daniela Trisciuoglio, Francesca Degrassi, Roberto Antonioletti, Daniela Trisciuoglio (132747), Renata Cozzi (651264), Gianandrea Traversi (6574112), David Staid (6574115), Mario Fiore (231517)   +17 more
core   +1 more source