A comparative evaluation of intranasal α2-adrenoceptor agonists and intranasal midazolam as premedication in pediatric sedation: A meta-analysis of randomized controlled trials. [PDF]
PLoS ONE, 2023 BackgroundMidazolam and α2-adrenoceptor agonists have been widely used off-label as intranasal sedatives for children. The present meta-analysis aimed to evaluate the effects of two interventions in pediatric sedation.MethodsPubMed, Embase, and Cochrane ...
Yuzhi Fu +3 more
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TYRAMINE REVEALS FAILING α2-ADRENOCEPTOR CONTROL OF CATECHOLAMINE RELEASE AND TOTAL PERIPEHRAL VASCULAR RESISTANCE IN HYPERTENSIVE RATS [PDF]
Frontiers in Neurology, 2013 α2-adrenoceptor-activation lowers central sympathetic output, peripheral, vesicular norepinephrine release, epinephrine secretion and modulates vascular tension.
Torill eBerg, Jørgen eJensen
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Cannabigerol modulates α2-adrenoceptor and 5-HT1A receptor-mediated electrophysiological effects on dorsal raphe nucleus and locus coeruleus neurons and anxiety behavior in rat [PDF]
Frontiers in Pharmacology, 2023 The pharmacological profile of cannabigerol (CBG), which acid form constitutes the main precursor of the most abundant cannabinoids, has been scarcely studied. It has been reported to target α2-adrenoceptor and 5-HT1A receptor.
Aitziber Mendiguren +5 more
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Methylphenidate improves prefrontal cortical cognitive function through α2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder [PDF]
Behavioral and Brain Functions, 2005 Background Methylphenidate (MPH) is the classic treatment for Attention Deficit Hyperactivity Disorder (ADHD), yet the mechanisms underlying its therapeutic actions remain unclear. Recent studies have identified an oral, MPH dose regimen which when given
Dudley Anne G, Arnsten Amy FT
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Effects of fadolmidine, an α2‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs [PDF]
Pharmacology Research & Perspectives, 2021 α2‐Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α2‐adrenoceptor agonist developed especially as a spinal analgesic.
Tiina Leino +4 more
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Immuno-oncological effects of the α2-adrenoceptor agonist dexmedetomidine [PDF]
OncoImmunologyThe α2-adrenergic receptor agonist dexmedetomidine (DEX) exerts context-dependent antitumor effects, with its efficacy influenced by dose, immune cell involvement and combination with immune checkpoint inhibitors.
Lucillia Bezu +2 more
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Frontiers in Pharmacology, 2022 Spinal α2-adrenoceptor induces analgesia by neuronal inhibition of primary afferent fibers. This family receptor coupled to Gi/o proteins can be subdivided into three functional subtypes: α2A, α2B, and α2C-adrenoceptors, and current evidence on spinal ...
Gustavo López-Córdoba +4 more
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Frontiers in Physiology, 2021 The prelimbic (PL) and infralimbic (IL) subareas of the medial prefrontal cortex (mPFC) have been implicated in physiological and behavioral responses during aversive threats. The previous studies reported the noradrenaline release within the mPFC during
Leandro A. Oliveira +8 more
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Pharmacology Research & Perspectives, 2022 α2‐Adrenoceptors, subdivided into α2A, α2B, and α2C subtypes and expressed in heart, blood vessels, kidney, platelets and brain, are important for blood pressure, sedation, analgesia, and platelet aggregation.
Richard G.W. Proudman +2 more
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Journal of Pharmacological Sciences, 2022 The stimulation of α2-adrenoceptors caused a transient increase of intracellular calcium concentration ([Ca2+]i) monitored by ratiometry using Fura-2 in epithelial cells including enterochromaffin cells in isolated mouse ileal crypts, while stimulation ...
Tomoko Kimyo +4 more
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