Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial [PDF]
, 2010 Introduction Benzodiazepines and α2 adrenoceptor agonists exert opposing effects on innate immunity and mortality in animal models of infection. We hypothesized that sedation with dexmedetomidine (an α2 adrenoceptor agonist), as compared with lorazepam ...
Pratik P Pandharipande +9 more
core +2 more sources
EFFECTS OF YOHIMBINE ON PLASMA LEVELS OF LEPTIN IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS [PDF]
Acta Medica Iranica, 2006 Leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action.
M. Mohammadi Naghadeh +2 more
doaj +2 more sources
The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension [PDF]
, 2012 Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease. One feature of hypertension is a hyperresponsiveness to contractile agents, and inhibition of vasoconstriction forms the basis
Roberts, Richard E.
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Striatal dopamine D-2 receptors attenuate neuropathic hypersensitivity in the rat [PDF]
, 2007 Earlier studies indicate that striatal dopamine D-2 receptors are involved in pain regulation in non-neuropathic conditions. We assessed whether striatal dopamine D-2 receptors contribute to pain regulation also in neuropathic conditions.
Ansah, Osei B. +3 more
core +1 more source
Current and prospective pharmacological targets in relation to antimigraine action [PDF]
, 2008 Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with
A Bergerot +335 more
core +5 more sources
Journal of Pharmacological Sciences, 2010 We investigated the roles of β- and α2-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced
Satoshi Deyama +6 more
doaj +1 more source
Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms. [PDF]
J NeuroendocrinolNorepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Lavoie O +6 more
europepmc +2 more sources
Mechanism of Selective Inhibition of Yohimbine and Its Derivatives in Adrenoceptor α2 Subtypes
Journal of Chemistry, 2013 Some natural alkaloids from medicinal plants, such as yohimbine and its derivatives, have been reported with adrenoceptor (AR) α2 subtypes inhibiting activity.
Liu Hai-Bo +4 more
doaj +1 more source
Evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging African lions (Panthera leo) [PDF]
, 2010 Objective To evaluate the effects of the combination butorphanol, medetomidine and midazolam (BMM) and its reversibility in lions. Study design Prospective clinical trial.
Bush +37 more
core +1 more source
Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
Journal of Pharmacological Sciences, 2011 We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elicited biting, an itch-related response, in sensitized mice.
Yoshikazu Gotoh +3 more
doaj +1 more source