Results 11 to 20 of about 8,213 (177)

Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats.

PLoS ONE, 2022
PurposeWe examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats.MethodsMale rats (226-301 g, n = 49) under isoflurane anesthesia had their tail vein ...
Yoichiro Kitajima, Nana Sato Hashizume, Chikako Saiki, Ryoji Ide, Toshio Imai   +4 more
doaj   +2 more sources

Opposing functions of α- and β-adrenoceptors in the formation of processes by cultured astrocytes

Journal of Pharmacological Sciences, 2021
Astrocytes are glial cells with numerous fine processes which are important for the functions of the central nervous system. The activation of β-adrenoceptors induces process formation of astrocytes via cyclic AMP (cAMP) signaling. However, the role of α-
Taisuke Kitano, Ryota Eguchi, Yuko Okamatsu-Ogura, Soichiro Yamaguchi, Ken-ichi Otsuguro   +4 more
doaj   +1 more source

Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundDexmedetomidine is a highly selective α2-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction ...
Seong-Ho Ok, Sung Il Bae, Haeng Seon Shim, Ju-Tae Sohn   +3 more
doaj   +1 more source

The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in Cell Models of Huntington’s Disease

Pharmaceuticals, 2021
Huntington’s disease (HD) is a monogenetic neurodegenerative disorder characterized by the accumulation of polyglutamine-expanded huntingtin (mHTT). There is currently no cure, and therefore disease-slowing remedies are sought to alleviate symptoms of ...
Elisabeth Singer, Lilit Hunanyan, Magda M. Melkonyan, Jonasz J. Weber, Lusine Danielyan, Huu Phuc Nguyen   +5 more
doaj   +1 more source

Dual alpha2C/5HT1A receptor agonist allyphenyline induces gastroprotection and inhibits fundic and colonic contractility [PDF]

, 2016
Allyphenyline, a novel α2-adrenoceptor (AR) ligand, has been shown to selectively activate α2C-adrenoceptors (AR) and 5HT1A receptors, but also to behave as a neutral antagonist of α2A-ARs.
A Fletcher, A Robert, AE Knaus, AJ Farre, AM Caballero-Plasencia, C Blandizzi, C Cardinaletti, DB Bylund, E Sangiovanni, EJ Dickson, F Bello Del, F Bello Del, F Gentili, F Ponti De, Fabio Del Bello, GB Glavin, GE Boeckxstaens, GR Davies, H Miwa, J Sallinen, J Tack, J Tack, J Tack, J Tack, J Tack, JD Altman, JF Tack, JJ Meana, JR Docherty, K Fülöp, K Gyires, K Gyires, K Gyires, K Gyires, K Gyires, K Gyires, K Gyires, K Hoshino, K Müllner, K Takeuchi, K Takeuchi, Klára Gyires, KP Makaritsis, L Hein, L Laine, L Oudenhove Van, L Xue, L Xue, L Zhang, László Köles, M Bardou, M Kaji, M Nagata, M Philipp, M Philipp, M Ubaldi, Mahmoud Al-Khrasani, Maria Pigini, N Shujaa, P Janssen, P Malfertheiner, PA Crassous, R Krysiak, RE Link, RM Sullivan, S Kwiecien, S Kwiecien, S Szabo, SA El-Maraghy, SJ Kim, Szabina Sipos, T Kemmerly, T Umezawa, T Yoshikawa, TA Voronina, TK Smith, Viktória E. Tóth, WD Paton, Y Tache, Zoltán S. Zádori, ZS Zádori, Ágnes Fehér   +81 more
core   +1 more source

Modulation of Noradrenergic Neurotransmission in Isolated Rat Radial Artery

Journal of Pharmacological Sciences, 2009
The present study was designed to characterize the neurogenic contraction of rat radial artery. Electrical field stimulation (EFS) evoked frequency-dependent contraction that was abolished by tetrodotoxin (neuronal Na+ channel blocker), guanethidine ...
Ana Cristina Martínez, Rosa María Pagán, Dolores Prieto, Paz Recio, Albino García-Sacristán, Medardo Hernández, Sara Benedito   +6 more
doaj   +1 more source

Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models

Frontiers in Pharmacology, 2020
Zerumbone has shown great potential in various pathophysiological models of diseases, particularly in neuropathic pain conditions. Further understanding the mechanisms of action is important to develop zerumbone as a potential anti-nociceptive agent ...
Jasmine Siew Min Chia, Jasmine Siew Min Chia, Noor Aishah Mohammed Izham, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Sanam Mustafa, Mark R. Hutchinson, Enoch Kumar Perimal, Enoch Kumar Perimal   +8 more
doaj   +1 more source

Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat

Clinical and Experimental Hypertension, 2019
Stimulation of α2-adrenoceptor/I1-imidazoline receptors in the rostral ventrolateral medulla decreases the blood pressure via sympathoinhibition. However, alteration of receptor responses in genetically hypertensive rats remains unclear.
Masanobu Yamazato, Minori Nakamoto, Atsushi Sakima, Yoriko Yamazato, Shuichi Takishita, Yusuke Ohya   +5 more
doaj   +1 more source

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. [PDF]

PLoS ONE, 2015
The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity.
Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Barbara Mordyl, Monika Głuch-Lutwin, Grzegorz Kazek, Jacek Sapa, Karolina Pytka   +9 more
doaj   +1 more source

Roles of α-Adrenoceptors and Sympathetic Nerve in Acute Herpetic Pain Induced by Herpes Simplex Virus Inoculation in Mice

Journal of Pharmacological Sciences, 2003
Percutaneous inoculation with herpes simplex virus type-1 brings about herpes zoster-like skin lesions, tactile allodynia, and mechanical hyperalgesia in mice.
Atsushi Sasaki, Ichiro Takasaki, Tsugunobu Andoh, Hiroshi Nojima, Kimiyasu Shiraki, Yasushi Kuraishi   +5 more
doaj   +1 more source