Results 51 to 60 of about 8,213 (177)

Dexmedetomidine for sedation in pediatric patients who received more than 20 sessions of radiation therapy: two cases report [PDF]

Korean Journal of Anesthesiology, 2016
Dexmedetomidine is a highly selective α2-adrenoceptor agonist that demonstrates anxiolytic and analgesic properties without inducing respiratory compromise, which makes it a suitable agent for procedural sedation and imaging studies.
Sun-Key Kim, Myung-Hee Song, Il-Jung Lee, Jae-Hyuk Lee, In-Cheol Choi   +4 more
doaj   +1 more source

Refined Division of Sleep Stages in the Mouse Based on Distributed Deep Electrodes and Underlying Infra‐Slow Oscillation

Journal of Sleep Research, EarlyView.
ABSTRACT The mouse sleep is mostly recorded with only epidural electrodes and divided simply into NREM and REM stages. With the help of distributed intracerebral triplet electrodes, we searched for possible new electrophysiological signatures to characterise more specific sleep substages within the timeframe of seconds to tens of minutes.
Nanxiang Jin, Sara Häkli, Keerthana Malathi, Hennariikka Koivisto, Theodor Boc, Jonas Schimmel, Eric Castell‐Caubet, Irina Gureviciene, Heikki Tanila   +8 more
wiley   +1 more source

Indirect involvement of α2-adrenoceptors in the mechanical antihypersensitivity effect induced by the spinally administered imidazoline I1 receptor ligand LNP599 in a rat model of experimental neuropathy

Brain Research Bulletin
Here we assess whether neuropathic pain hypersensitivity is attenuated by spinal administration of the imidazoline I1-receptor agonist LNP599 and whether the attenuation involves co-activation of α2-adrenoceptors.
Hong Wei, Anne Vuorenpää, Jonne Laurila, Andrii Domanskyi, Ari Koivisto, Antti Pertovaara   +5 more
doaj   +1 more source

Suppression of osteoclastogenesis via α2-adrenergic receptors [PDF]

, 2018
The sympathetic nervous system is known to regulate osteoclast development. However, the involvement of α2-adrenergic receptors (α2-ARs) in osteoclastogenesis is not well understood.
Chen, Andy, Goto, Shigemi, Hamajima, Kosuke, Hamamura, Kazunori, Hirai, Takao, Ishizuka, Kyoko, Kodama, Daisuke, Kondo, Hisataka, Miyazawa, Ken, Mori, Hironori, Tanaka, Kenjiro, Togari, Akifumi, Yo, Shoyoku, Yokota, Hiroki   +13 more
core   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Vasopressors for cardiopulmonary resuscitation. Does pharmacological evidence support clinical practice? [PDF]

Adrenaline (epinephrine) has been used for cardiopulmonary resuscitation (CPR) since 1896. The rationale behind its use is thought to be its alpha-adrenoceptor-mediated peripheral vasoconstriction, causing residual blood flow to be diverted to coronary ...
Broadley, KJ, Ford, WR, Penson, P
core   +1 more source

Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats [PDF]

, 2009
Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in telemetered female rats. Main methods—The effects of
Abdel A. Abdel-Rahman, Abdel-Rahman, Badoer, Biaggioni, Bousquet, Bousquet, Chan, Collins, Dupuy, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, Elghozi, Ernsberger, Girard, Janssen, Karkanias, Kohno, Kubo, Laurent, Lokhandwala, Mahmoud M. El-Mas, Piletz, Puddey, Sgoifo, Stein, Sweet, Szmigielski, Timio, Timmermans, Tobe, Tulen, van der Maas, van Zwieten, van Zwieten, Volicer   +40 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Adrenergic Drugs Blockers or Enhancers for Cognitive Decline ? What to Choose for Alzheimer's Disease Patients? [PDF]

, 2016
The adrenergic system has an important role in normal central nervous system function as well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is involved in the regulation of learning and memory, reinforcement of ...
FEMMINELLA, GRAZIA DANIELA, FERRARA, NICOLA, LEOSCO, DARIO, RENGO, GIUSEPPE   +3 more
core   +1 more source