Results 61 to 70 of about 8,213 (177)

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Pain Modulation and Central Sensitization in Painful Diabetic Peripheral Neuropathy: Updated Narrative Review and Future Directions

Journal of Diabetes, Volume 18, Issue 4, April 2026.
Alterations within the central nervous system in painful diabetic peripheral neuropathy. Collectively, the changes in forebrain–thalamus connectivity, midbrain–brainstem projections and activities, and hindbrain structures weaken descending modulation of spinal sensory neurons, thereby increasing central sensitization.
Di Ye, Timothy J. Fairchild, Lechi Vo, Peter D. Drummond   +3 more
wiley   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice

Journal of Pharmacological Sciences, 2005
In this study, the antinociceptive effect of shakuyakukanzoto was investigated using streptozotocin-induced diabetic mice to certify its analgesic effect on diabetic patients.
Yuji Omiya, Yasuyuki Suzuki, Mitsutoshi Yuzurihara, Mikio Murata, Masaki Aburada, Yoshio Kase, Shuichi Takeda   +6 more
doaj   +1 more source

Effect of intracerebroventricular epinephrine microinjection on blood pressure and urinary sodium handling in gestational protein-restricted male adult rat offspring

Biology Open, 2019
In this study, we hypothesized that blunting of the natriuresis response to intracerebroventricularly (ICV) microinjected adrenergic agonists is involved in the development of hypertension in maternal low-protein intake (LP) offspring.
Bárbara Vaccari Cardoso, Augusto Henrique Custódio, Patrícia Aline Boer, José Antonio Rocha Gontijo   +3 more
doaj   +1 more source

Analgesic and Antidiarrheal Properties of Lappaconitine, Possibly Through Cyclooxygenase and µ‐Opioid Receptor Interaction Pathways: In Vivo and In Silico Studies

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Lappaconitine (LAP) is a diterpenoid alkaloid with strong anti‐inflammatory activity. However, there is limited information on its gastroprotective effects. The present study aimed to explore the analgesic and antidiarrheal effects of LAP through in vivo and in silico studies.
Shahid Shah, Arifa Akter, Salehin Sheikh, Razina Rouf, Raihan Chowdhury, Jannatul Ferdous, Md. Shimul Bhuia, Imam Hossain Rakib, Md. Zahid Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam   +11 more
wiley   +1 more source

Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats [PDF]

, 2007
Merged planning photographs of [284] southern pavilion rubble fill removed to reveal ditch fill and natural; facing west; linked as external references to excavation plan 'Thwing_4-2_excavation_plan ...
Chung-Hung Shih, Yu-Jing Lin, Chi-Ming Chen, Wun-Chang Ko   +3 more
core   +2 more sources

Heightened SAM- and HPA-axis activity during acute stress impairs decision-making: A systematic review on underlying neuropharmacological mechanisms

Neurobiology of Stress
Individuals might be exposed to intense acute stress while having to make decisions with far-reaching consequences. Acute stress impairs processes required for decision-making by activating different biological stress cascades that in turn affect the ...
Lukas van Herk, Frank P.M. Schilder, Antoin D. de Weijer, Bastiaan Bruinsma, Elbert Geuze   +4 more
doaj   +1 more source

Role of α2-Adrenoceptors in Hypertension: Focus on Renal Sympathetic Neurotransmitter Release, Inflammation, and Sodium Homeostasis

Frontiers in Physiology, 2020
The kidney is extensively innervated by sympathetic nerves playing an important role in the regulation of blood pressure homeostasis. Sympathetic nerve activity is ultimately controlled by the central nervous system (CNS).
Lydia Hering, Masudur Rahman, Sebastian A. Potthoff, Lars C. Rump, Johannes Stegbauer   +4 more
doaj   +1 more source

The role of BK potassium channels in analgesia produced by alpha-2 adrenergic receptors [PDF]

, 2016
BACKGROUND AND OBJECTIVE: Millions of people suffer from pain worldwide, and annually, great economic costs are imposed on societies for pain relief. Analgesics such as alpha-2 adrenergic receptor agonists, which have low risk of complications, can be ...
Attarzadeh-Yazd, G., Houshmand, E., Jahanshahi, M.   +2 more
core   +1 more source